Substance
ID:361590
Names and Identifiers
IUPAC name
1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione
IUPAC Traditional name
turmeric
Synonyms
DiferulylmethaneCurcumin(E,E)-1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dioneDiferuloylmethaneNatural Yellow 3
Registration numbers
CAS Number
MDL Number
EC Number
Color Index Number
E Number
Beilstein Number
Properties
Product Information
Grade
analytical standard
Purity
≥98.0% (HPLC)
Linear Formula
[HOC6H3(OCH3)CH=CHCO]2CH2
Shelf Life
(limited shelf life, expiry date on the label)
Safety Information
Safety Statements
26-36/37/39
Storage Temperature
2-8°C
GHS Precautionary statements
P261-P305+P351+P338
GHS Signal Word
Warning
RTECS
MI5230000
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
European Hazard Symbols
Irritant (Xi)GHS Hazard statements
H315-H319-H335
Risk Statements
36/37/38
MSDS Link
German water hazard class
3
Physical Property
Vapor Density
13 (vs air)
Molecule Details
Biochem/physiol Actions
A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. Curcumin has been cited as a potential chemopreventive agent, in addition to its chemotherapeutic activity.1 Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope.
A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. Curcumin has been cited as a potential chemopreventive agent, in addition to its chemotherapeutic activity.1 Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope.
Molecular Spectra
No Data Available
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References
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