Substance
ID:359400
Names and Identifiers
IUPAC name
3-[dimethyl({3-[(4R)-4-[(1S,2S,5R,9R,10R,11S,14R,15R,16S)-5,9,16-trihydroxy-2,15-dimethyltetracyclo[8.7.0.02,7.011,15]heptadecan-14-yl]pentanamido]propyl})azaniumyl]propane-1-sulfonate
IUPAC Traditional name
3-[dimethyl({3-[(4R)-4-[(1S,2S,5R,9R,10R,11S,14R,15R,16S)-5,9,16-trihydroxy-2,15-dimethyltetracyclo[8.7.0.02,7.011,15]heptadecan-14-yl]pentanamido]propyl})ammonio]propane-1-sulfonate
Synonyms
3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulfonate3-[(3-胆酰胺丙基)二甲氨基]丙磺酸内盐CHAPS
Properties
Product Information
Cation Traces
Fe: ≤5 mg/kg
Cu: ≤5 mg/kg
K: ≤50 mg/kg
Co: ≤5 mg/kg
Na: ≤50 mg/kg
Zn: ≤5 mg/kg
Ca: ≤10 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Ni: ≤5 mg/kg
Cd: ≤5 mg/kg
Pb: ≤5 mg/kg
Cr: ≤5 mg/kg
Description
zwitterionic
Mol. Weight
micellar avg mol wt 6150
Empirical Formula (Hill Notation)
C32H58N2O7S
Purity
≥98.0% (TLC)
Antion Traces
sulfate (SO42-): ≤50 mg/kg
chloride (Cl-): ≤50 mg/kg
Impurities
≤8% water
Physical Property
Solubility
H2O: soluble50 mg/mL at 20 °C, clear, colorless
Critical Micelle Concentration
6 mM(20-25°C)
Aggregation Number of Micelle
10
Transition Temperature
cloud point >100 °C
Safety Information
Risk Statements
61
MSDS Link
Safety Statements
53-45
German water hazard class
-
European Hazard Symbols
Toxic (T)Molecule Details
Application
CHAPS is a nondenaturing zwitterionic detergent for membrane biochemistry.Useful for solubilizing membrane proteins and breaking protein-protein interactions. CHAPS’ small micellar molecular weight (6,150) and high critical micelle concentration (6-10 mM) allow it to be removed from samples by dialysis. It is also suitable for protein solubilization for isoelectric focusing and two-dimensional electrophoresis. CHAPS is commonly used for non-denaturing (without urea) IEF and has been shown to give excellent resolution of some subcellular preparations and plant proteins. Concentrations between 2-4% (w/v) are typically used in an IEF gel.
Other Notes
Zwitterionic detergent for the solubilisation of membrane proteins. Combines the useful properties of both the sulfobetaine-type and the bile salt detergents1,2; As a non-toxic stabilizing agent for growth factors3
CHAPS is a nondenaturing zwitterionic detergent for membrane biochemistry.Useful for solubilizing membrane proteins and breaking protein-protein interactions. CHAPS’ small micellar molecular weight (6,150) and high critical micelle concentration (6-10 mM) allow it to be removed from samples by dialysis. It is also suitable for protein solubilization for isoelectric focusing and two-dimensional electrophoresis. CHAPS is commonly used for non-denaturing (without urea) IEF and has been shown to give excellent resolution of some subcellular preparations and plant proteins. Concentrations between 2-4% (w/v) are typically used in an IEF gel.
Other Notes
Zwitterionic detergent for the solubilisation of membrane proteins. Combines the useful properties of both the sulfobetaine-type and the bile salt detergents1,2; As a non-toxic stabilizing agent for growth factors3
Molecular Spectra
No Data Available
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References
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