Substance
ID:358923
Names and Identifiers
IUPAC Traditional name
floxuridine
IUPAC name
5-fluoro-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione
Synonyms
Floxuridine5-Fluoro-2′-deoxyuridine2′-Deoxy-5-fluorouridineFUDR
Properties
Safety Information
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
RTECS
YU7525000
Packing Group
3
GHS Signal Word
Danger
Hazard Class
6.1
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), categories 1,2,3
German water hazard class
3
GHS Precautionary statements
P301+P310
Risk Statements
22
Safety Statements
22-36
UN Number
2811
Storage Temperature
2-8°C
GHS Hazard statements
H301
RID/ADR
UN 2811 6.1/PG 3
European Hazard Symbols
Harmful (Xn)MSDS Link
Product Information
Empirical Formula (Hill Notation)
C9H11FN2O5
Purity
≥98.0% (HPLC)
Physical Property
Optical Rotation
[α]20/D +38±1°, c = 1% in H2O
Melting Point
148-150 °C
148 °C(lit.)
Molecule Details
Biochem/physiol Actions
Antineoplastic drug that acts as a potent inhibitor of thymidylate synthetase1 Resistance to FUdR can develop in cancer cell cultures, among other means, by low-level Mycoplasma infection.2
Other Notes
Inhibits DNA synthesis by prior inhibition of thymidylate synthetase3
Antineoplastic drug that acts as a potent inhibitor of thymidylate synthetase1 Resistance to FUdR can develop in cancer cell cultures, among other means, by low-level Mycoplasma infection.2
Other Notes
Inhibits DNA synthesis by prior inhibition of thymidylate synthetase3
Molecular Spectra
No Data Available
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References
No Data Available
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