Substance
ID:358125
Names and Identifiers
IUPAC name
(2S)-2-amino-4-{[(1R)-1-[(carboxymethyl)carbamoyl]-2-sulfanylethyl]carbamoyl}butanoic acid
IUPAC Traditional name
glutathione
Synonyms
5-L-谷氨酰-L-半胱氨酰甘氨酸γ-L-Glutamyl-L-cysteinyl-glycineL-还原型谷胱甘肽GSHL-Glutathione reduced
Registration numbers
Beilstein Number
MDL Number
EC Number
CAS Number
Properties
Product Information
Cation Traces
Ni: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
K: ≤5 mg/kg
Cd: ≤5 mg/kg
Na: ≤50 mg/kg
Co: ≤5 mg/kg
Fe: ≤5 mg/kg
Ca: ≤10 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Pb: ≤5 mg/kg
Zn: ≤5 mg/kg
Purity
≥97.0% (sum of enantiomers, HPLC)
Impurities
≤1% L-glutathione oxid. (enzymatic)
Linear Formula
H2NCH(CO2H)CH2CH2CONHCH(CH2SH)CONHCH2CO2H
Safety Information
Storage Temperature
2-8°C
MSDS Link
Personal Protective Equipment
Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
German water hazard class
2
RTECS
MC0556000
Physical Property
Optical Rotation
[α]20/D -17±1°, c = 2% in H2O
Melting Point
192-195 °C (dec.)(lit.)
Molecule Details
Amino Acid Sequence
γ-Glu-Cys-Gly
Application
May be used at 5-10 mM to elute glutathione S-transferase (GST) from glutathione agarose.
Biochem/physiol Actions
Endogenous antioxidant that plays a major role in reducing reactive oxygen species formed during cellular metabolism and the respiratory burst. Glutathione-S-transferase catalyzes the formation of glutathione thioethers with xenobiotics, leukotrienes, and other molecules that have an electrophilic center. Glutathione also forms disulfide bonds with cysteine residues in proteins. Via these mechanisms, it can have the paradoxical effect of reducing the efficacy of anti-cancer agents.
γ-Glu-Cys-Gly
Application
May be used at 5-10 mM to elute glutathione S-transferase (GST) from glutathione agarose.
Biochem/physiol Actions
Endogenous antioxidant that plays a major role in reducing reactive oxygen species formed during cellular metabolism and the respiratory burst. Glutathione-S-transferase catalyzes the formation of glutathione thioethers with xenobiotics, leukotrienes, and other molecules that have an electrophilic center. Glutathione also forms disulfide bonds with cysteine residues in proteins. Via these mechanisms, it can have the paradoxical effect of reducing the efficacy of anti-cancer agents.
Molecular Spectra
No Data Available
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References
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