Substance
ID:357550
Names and Identifiers
Synonyms
3-[4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-L-alanineT4L-Thyroxine3,3′,5,5″-四碘代-L-甲状腺原氨酸L-甲状腺素3,3′,5,5″-Tetraiodo-L-thyronine3-[4-(4-羟基-3,5-二碘苯氧基)-3,5-二碘苯基]-L-丙氨酸
IUPAC name
(2S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid
IUPAC Traditional name
levothyroxine
Registration numbers
MDL Number
EC Number
Beilstein Number
CAS Number
Properties
Pharmacology Properties
Gene Information
human ... TTR(7276)
Safety Information
Personal Protective Equipment
Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
German water hazard class
3
Storage Temperature
2-8°C
MSDS Link
RTECS
YP2833500
Physical Property
Melting Point
~235 °C (dec.)
223 °C (dec.)(lit.)
Optical Rotation
[α]20/D -5.3±0.5°, c = 1% in ethanol/1 M NaOH (2:1)
Product Information
Linear Formula
HOC6H2(I)2OC6H2(I)2CH2CH(NH2)CO2H
Purity
≥97.0% (sum of enantiomers, HPLC)
Molecule Details
Biochem/physiol Actions
L-Thyroxine (T4) and triiodo-L-thyronine (T3) are iodine-containing hormones produced from thyroglobulin in the thyroid follicular cells. The stimulation of metabolic rate and regulation of growth and development by these hormones appear to be due to their effects on DNA transcription and, thus, protein synthesis.
Other Notes
Review1
L-Thyroxine (T4) and triiodo-L-thyronine (T3) are iodine-containing hormones produced from thyroglobulin in the thyroid follicular cells. The stimulation of metabolic rate and regulation of growth and development by these hormones appear to be due to their effects on DNA transcription and, thus, protein synthesis.
Other Notes
Review1
Molecular Spectra
No Data Available
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References
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