Substance
ID:357501
Names and Identifiers
IUPAC Traditional name
wortmannin
IUPAC name
(1R,3R,5S,9R,18S)-18-(methoxymethyl)-1,5-dimethyl-6,11,16-trioxo-13,17-dioxapentacyclo[10.6.1.02,10.05,9.015,19]nonadeca-2(10),12(19),14-trien-3-yl acetate
Synonyms
KY 12420Wortmannin
Properties
Safety Information
GHS Precautionary statements
P260-P264-P280-P284-P302+P350-P310
RID/ADR
UN 3462 6.1/PG 1
RTECS
CB9641000
Storage Temperature
2-8°C
Risk Statements
26/27/28
Safety Statements
28-36/37-45
GHS Hazard statements
H300-H310-H330
European Hazard Symbols
Highly toxic (T+)Personal Protective Equipment
Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
GHS Signal Word
Danger
MSDS Link
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), categories 1,2,3
UN Number
3462
German water hazard class
3
Packing Group
1
Hazard Class
6.1
Product Information
Empirical Formula (Hill Notation)
C23H24O8
Purity
≥98.0% (TLC)
Molecule Details
Biochem/physiol Actions
Wortmannin is a potent and specific phosphatidylinositol 3-kinase (PI3-K) inhibitor with an IC50 of 2-4 nM. Inhibition of PI3-K/Akt signal transduction cascade enhances the apoptotic effects of radiation or serum withdrawal and blocks the antiapoptotic effect of cytokines. Inhibition of PI3-K by wortmannin also blocks many of the short-term metabolic effects induced by insulin receptor activation.
Wortmannin is a potent and specific phosphatidylinositol 3-kinase (PI3-K) inhibitor with an IC50 of 2-4 nM. Inhibition of PI3-K/Akt signal transduction cascade enhances the apoptotic effects of radiation or serum withdrawal and blocks the antiapoptotic effect of cytokines. Inhibition of PI3-K by wortmannin also blocks many of the short-term metabolic effects induced by insulin receptor activation.
Molecular Spectra
No Data Available
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References
No Data Available
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