Substance
ID:356884
Names and Identifiers
IUPAC Traditional name
cytarabine
Synonyms
Ara-CArabinocytidineCytosine arabinosideArabinosylcytosine胞嘧啶 β-D-呋喃阿拉伯糖苷阿糖胞苷Cytosine β-D-arabinofuranoside胞嘧啶阿拉伯糖苷阿糖胞嘧啶(β-D-阿拉伯呋喃糖基)胞嘧啶阿拉伯糖胞嘧啶(β-D-Arabinofuranosyl)cytosineCytarabine
IUPAC name
4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydropyrimidin-2-one
Registration numbers
CAS Number
Beilstein Number
EC Number
MDL Number
PubChem SID
Properties
Safety Information
Safety Statements
36/37
RTECS
HA5425000
GHS Signal Word
Warning
Risk Statements
63-43
GHS Precautionary statements
P280
Personal Protective Equipment
Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
German water hazard class
3
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
Respiratory sensitization, category 1
Germ cell mutagenicity, categories 1A,1B,2
Carcinogenicity, categories 1A,1B,2
Reproductive toxicity, categories 1A,1B,2
Specific Target Organ Toxicity – Single exposure, categories 1,2
Specific Target Organ Toxicity – Repeated exposure, categories 1,2
Aspiration Hazard, category 1
European Hazard Symbols
Harmful (Xn)GHS Hazard statements
H317-H361
MSDS Link
Product Information
Empirical Formula (Hill Notation)
C9H13N3O5
Purity
≥99.0% (HPLC)
Pharmacology Properties
Gene Information
human ... POLB(5423)mouse ... Cda(72269)
Physical Property
Solubility
H2O: soluble50 mg/mL, clear, colorless
Optical Rotation
[α]20/D +158±2°, c = 1% in H2O
Molecule Details
Biochem/physiol Actions
Ara-C incorporates into DNA and inhibits DNA replication by forming cleavage complexes with topoisomerase I resulting in DNA fragmentation; does not inhibit RNA synthesis. Anti-leukemia agent.
Ara-C incorporates into DNA and inhibits DNA replication by forming cleavage complexes with topoisomerase I resulting in DNA fragmentation; does not inhibit RNA synthesis. Anti-leukemia agent.
Molecular Spectra
No Data Available
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References
No Data Available
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