Substance
ID:354871
Names and Identifiers
IUPAC Traditional name
brefeldin A
IUPAC name
(1R,6S,11aS,13S,14aR)-1,13-dihydroxy-6-methyl-1H,4H,6H,7H,8H,9H,11aH,12H,13H,14H,14aH-cyclopenta[f]oxacyclotridecan-4-one
Synonyms
γ,4-Dihydroxy-2-(6-hydroxy-1-heptenyl)-4-cyclopentanecrotonic acid λ-lactoneCyaneinBrefeldin ADecumbinBFAAscotoxin
Properties
Safety Information
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), categories 1,2,3
Storage Temperature
2-8°C
Hazard Class
6.1
GHS Precautionary statements
P301+P310
GHS Hazard statements
H301
European Hazard Symbols
Harmful (Xn)Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Risk Statements
22
GHS Signal Word
Danger
MSDS Link
UN Number
2811
German water hazard class
3
RID/ADR
UN 2811 6.1/PG 3
Packing Group
3
RTECS
GY8410000
Physical Property
Melting Point
200-205 °C
Solubility
methanol: soluble10 mg/mL, clear, colorless to faintly yellow
Product Information
Empirical Formula (Hill Notation)
C16H24O4
Purity
≥99.0% (TLC)
Biological Source
from Penicillium brefeldianum
Molecule Details
Other Notes
Effects a rapid increase of Golgi cisternae volume and subsequent loss of recognizable Golgi apparatus in treated cells1,2.
Biochem/physiol Actions
Brefeldin A (BFA) is a fungal metabolite which disrupts the structure and function of the Golgi apparatus. BFA is an activator of the sphingomyelin cycle. Brefeldin A-mediated apoptosis has been observed in human tumor cells.
Effects a rapid increase of Golgi cisternae volume and subsequent loss of recognizable Golgi apparatus in treated cells1,2.
Biochem/physiol Actions
Brefeldin A (BFA) is a fungal metabolite which disrupts the structure and function of the Golgi apparatus. BFA is an activator of the sphingomyelin cycle. Brefeldin A-mediated apoptosis has been observed in human tumor cells.
Molecular Spectra
No Data Available
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References
No Data Available
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