Substance
ID:354821
Names and Identifiers
IUPAC Traditional name
hydroxyurea
IUPAC name
hydroxyurea
Synonyms
Hydroxycarbamide羟基脲Hydroxyurea
Registration numbers
CAS Number
MDL Number
Beilstein Number
EC Number
PubChem SID
Properties
Product Information
Purity
≥98.0% (N)
Linear Formula
NH2CONHOH
Pharmacology Properties
Gene Information
human ... CA1(759), CA2(760), CYP1A2(1544), RRM1(6240)
Physical Property
Melting Point
135-140 °C
Safety Information
Safety Statements
53-36/37-45
RTECS
YT4900000
European Hazard Symbols
Toxic (T)Risk Statements
46-63
GHS Signal Word
Danger
MSDS Link
GHS Pictograms
Respiratory sensitization, category 1
Germ cell mutagenicity, categories 1A,1B,2
Carcinogenicity, categories 1A,1B,2
Reproductive toxicity, categories 1A,1B,2
Specific Target Organ Toxicity – Single exposure, categories 1,2
Specific Target Organ Toxicity – Repeated exposure, categories 1,2
Aspiration Hazard, category 1
GHS Hazard statements
H340-H361
Personal Protective Equipment
Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
GHS Precautionary statements
P201-P281-P308+P313
German water hazard class
3
Molecule Details
Biochem/physiol Actions
Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase.
Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase.
Molecular Spectra
No Data Available
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References
No Data Available
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