Substance
ID:354810
Names and Identifiers
IUPAC name
(3R,4S,5R)-3,4,5,6-tetrahydroxyhexanal
IUPAC Traditional name
deoxyglucose
Synonyms
2-脱氧-D-葡糖D-2-脱氧葡萄糖2-Deoxy-D-glucose2-Deoxy-D-arabinohexose
Registration numbers
CAS Number
EC Number
MDL Number
Beilstein Number
Properties
Physical Property
Optical Rotation
[α]20/D +46.5±2°, 45 hr, c = 0.5% in H2O
Melting Point
146-147 °C(lit.)
148-153 °C
Solubility
H2O: soluble50 mg/mL, clear, colorless to faintly yellow
Product Information
Empirical Formula (Hill Notation)
C6H12O5
Purity
≥98.0% (HPLC)
Safety Information
MSDS Link
Personal Protective Equipment
Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
German water hazard class
3
Molecule Details
Biochem/physiol Actions
2-Deoxy-D-Glucose (2-Deoxyglucose) is a glucose analog that inhibits glycolysis via its actions on hexokinase, the rate limiting step of glycolysis. It is phosphorylated by hexokinase to 2-DG-P which can not be further metabolized by phosphoglucose isomerase. This leads to the accumulation of 2-DG-P in the cell and the depletion in cellular ATP. In vitro, 2-Deoxyglucose has been shown to induce autophagy, increase ROS production, and activate AMPK.1
2-Deoxy-D-Glucose (2-Deoxyglucose) is a glucose analog that inhibits glycolysis via its actions on hexokinase, the rate limiting step of glycolysis. It is phosphorylated by hexokinase to 2-DG-P which can not be further metabolized by phosphoglucose isomerase. This leads to the accumulation of 2-DG-P in the cell and the depletion in cellular ATP. In vitro, 2-Deoxyglucose has been shown to induce autophagy, increase ROS production, and activate AMPK.1
Molecular Spectra
No Data Available
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References
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