Substance
ID:354797
Names and Identifiers
Synonyms
1-甲基-3-异丁基黄嘌呤3,7-二氢-1-甲基-3-(2-甲基丙基)-1H-嘌呤-2,6-二酮3-异丁基-1-甲基黄嘌呤3-异丁基-1-甲基-2,6(1H,3H)-嘌呤二酮3-Isobutyl-1-methylxanthineIBMX1-Methyl-3-isobutylxanthine3-Isobutyl-1-methyl-2,6(1H,3H)-purinedione3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione
IUPAC Traditional name
3 isobutyl 1 methylxanthine
IUPAC name
1-methyl-3-(2-methylpropyl)-2,3,6,7-tetrahydro-1H-purine-2,6-dione
Registration numbers
EC Number
CAS Number
Beilstein Number
MDL Number
Properties
Product Information
Purity
≥98.0% (HPLC)
Empirical Formula (Hill Notation)
C10H14N4O2
Grade
purum
Safety Information
GHS Hazard statements
H302
MSDS Link
GHS Signal Word
Warning
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
European Hazard Symbols
Harmful (Xn)RTECS
ZD8500000
Risk Statements
22
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
German water hazard class
3
Physical Property
Melting Point
201-203 °C
200-201 °C(lit.)
Molecule Details
Other Notes
Raises intracellular cyclic AMP levels2; Produces partial inhibition of cAMP-phosphodiesterase3
Biochem/physiol Actions
Non-specific inhibitor of cAMP and cGMP phosphodiesterases. The increase in cAMP level as a result of phosphodiesterase inhibition by IBMX activates PKA leading to decreased proliferation, increased differentiation, and induction of apoptosis. IBMX inhibits phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50: 1.3 μM). Also serves as an adenosine receptor antagonist. Shown to inhibit ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. Induces calcium release from intracellular stores in sensory neurons.1
Raises intracellular cyclic AMP levels2; Produces partial inhibition of cAMP-phosphodiesterase3
Biochem/physiol Actions
Non-specific inhibitor of cAMP and cGMP phosphodiesterases. The increase in cAMP level as a result of phosphodiesterase inhibition by IBMX activates PKA leading to decreased proliferation, increased differentiation, and induction of apoptosis. IBMX inhibits phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50: 1.3 μM). Also serves as an adenosine receptor antagonist. Shown to inhibit ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. Induces calcium release from intracellular stores in sensory neurons.1
Molecular Spectra
No Data Available
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References
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