Substance
ID:354326
Names and Identifiers
Synonyms
Staurosporine from Streptomyces sp.Antibiotic AM-2282
IUPAC Traditional name
(2S,3R,4R,6S)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8(13),9,11,14(28),15(19),20(27),21,23,25-nonaen-16-one
IUPAC name
(2S,3R,4R,6S)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8(13),9,11,14(28),15(19),20(27),21,23,25-nonaen-16-one
Properties
Product Information
Empirical Formula (Hill Notation)
C28H26N4O3
Purity
≥95.0% (HPLC)
Safety Information
GHS Precautionary statements
P201-P308+P313
European Hazard Symbols
Toxic (T)Storage Temperature
2-8°C
MSDS Link
GHS Signal Word
Danger
Safety Statements
53-45
GHS Pictograms
Respiratory sensitization, category 1
Germ cell mutagenicity, categories 1A,1B,2
Carcinogenicity, categories 1A,1B,2
Reproductive toxicity, categories 1A,1B,2
Specific Target Organ Toxicity – Single exposure, categories 1,2
Specific Target Organ Toxicity – Repeated exposure, categories 1,2
Aspiration Hazard, category 1
GHS Hazard statements
H340-H350
Personal Protective Equipment
Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
German water hazard class
3
Risk Statements
45-46
Molecule Details
Biochem/physiol Actions
Potent inhibitor of phospholipid/calcium-dependent protein kinase. Inhibits the upregulation of VEGF expression in tumor cells.
Other Notes
A potent inhibitor of phospholipid / calcium dependent protein kinase1,2; Inhibits the respiratory burst and induces exocytosis in human neutrophils3
Potent inhibitor of phospholipid/calcium-dependent protein kinase. Inhibits the upregulation of VEGF expression in tumor cells.
Other Notes
A potent inhibitor of phospholipid / calcium dependent protein kinase1,2; Inhibits the respiratory burst and induces exocytosis in human neutrophils3
Molecular Spectra
No Data Available
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References
No Data Available
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