Substance
ID:352356
Names and Identifiers
IUPAC Traditional name
digoxin
IUPAC name
4-[(1S,2S,5S,7R,10R,11S,14R,15S,16R)-5-{[(2R,4S,5S,6R)-5-{[(2S,4S,5S,6R)-5-{[(2S,4S,5S,6R)-4,5-dihydroxy-6-methyloxan-2-yl]oxy}-4-hydroxy-6-methyloxan-2-yl]oxy}-4-hydroxy-6-methyloxan-2-yl]oxy}-11,16-dihydroxy-2,15-dimethyltetracyclo[8.7.0.02,7.011,15]heptadecan-14-yl]-2,5-dihydrofuran-2-one
Synonyms
异羟基洋地黄毒苷Digoxin地高辛12β-Hydroxydigitoxin
Registration numbers
CAS Number
EC Number
Beilstein Number
MDL Number
PubChem SID
Properties
Safety Information
German water hazard class
3
GHS Signal Word
Danger
GHS Precautionary statements
P260-P264-P284-P301+P310-P310
European Hazard Symbols
Toxic (T)MSDS Link
RTECS
IH6125000
Packing Group
2
Risk Statements
23/25
Personal Protective Equipment
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
RID/ADR
UN 3462 6.1/PG 2
Safety Statements
22-36/37/39-45
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), categories 1,2,3
Hazard Class
6.1
UN Number
3462
GHS Hazard statements
H300+H330
Pharmacology Properties
Gene Information
human ... ABCB1(5243), CYP3A4(1576)mouse ... Abcb1a(18671), Abcb1b(18669)rat ... Atp1a1(24211)
Product Information
Empirical Formula (Hill Notation)
C41H64O14
Loss on Drying
≤1% loss on drying, 110 °C
Ignition Residue
≤0.1%
Purity
≥95.0% (HPLC)
Physical Property
Optical Rotation
[α]20/D +11.5±1.5°, c = 10% in pyridine
Molecule Details
Biochem/physiol Actions
A cardiac glycoside, substrate for Pgp, upregulates Pgp expression and down regulates SXR (Steroid Xenobiotic Receptor).
A cardiac glycoside, substrate for Pgp, upregulates Pgp expression and down regulates SXR (Steroid Xenobiotic Receptor).
Molecular Spectra
No Data Available
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References
No Data Available
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