Substance
ID:352313
Names and Identifiers
Synonyms
咖啡因1,3,7-三甲基黄嘌呤Caffeine1,3,7-Trimethylxanthine
IUPAC Traditional name
caffeine
IUPAC name
1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione
Properties
Product Information
Empirical Formula (Hill Notation)
C8H10N4O2
Purity
≥99.0% (HPLC)
Grade
purum
Safety Information
UN Number
1544
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
RTECS
EV6475000
MSDS Link
Risk Statements
22
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
Hazard Class
6.1
Packing Group
3
GHS Hazard statements
H302
RID/ADR
UN 1544 6.1/PG 3
GHS Signal Word
Warning
European Hazard Symbols
Harmful (Xn)German water hazard class
1
Physical Property
Melting Point
234-236.5 °C(lit.)
233-238 °C
Pharmacology Properties
Gene Information
human ... ADORA1(134), PDE4B(5142)
Molecule Details
Other Notes
Pharmacology and toxicology1
Biochem/physiol Actions
A central nervous system stimulant believed to act through adenosine receptors and monoamine neurotransmitters. It is an adenosine receptor antagonist and adenosine 3′,5′-cyclic monophosphate (cAMP) phosphodiesterase inhibitor. Thus, levels of cAMP increase in cells following treatment with caffeine. It has been reported to affect cellular calcium levels, releasing calcium from intracellular stores. It overrides the cell cycle effects of various chemicals such as protease inhibitors, preventing apoptosis; and it has been shown to inhibit cellular DNA repair mechanisms.
Pharmacology and toxicology1
Biochem/physiol Actions
A central nervous system stimulant believed to act through adenosine receptors and monoamine neurotransmitters. It is an adenosine receptor antagonist and adenosine 3′,5′-cyclic monophosphate (cAMP) phosphodiesterase inhibitor. Thus, levels of cAMP increase in cells following treatment with caffeine. It has been reported to affect cellular calcium levels, releasing calcium from intracellular stores. It overrides the cell cycle effects of various chemicals such as protease inhibitors, preventing apoptosis; and it has been shown to inhibit cellular DNA repair mechanisms.
Molecular Spectra
No Data Available
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References
No Data Available
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