Substance
ID:352232
Names and Identifiers
IUPAC name
bis(propan-2-yl) fluorophosphonate
IUPAC Traditional name
isoflurophate
Synonyms
DFP氟磷酸二异丙酯二异丙基氟磷酸酯DIFP氟代磷酸二异丙酯DiisopropylfluorophosphateDiisopropyl phosphorofluoridatePhosphoric acid diisopropyl ester fluoride
Registration numbers
CAS Number
MDL Number
Beilstein Number
EC Number
PubChem SID
Properties
Safety Information
Packing Group
1
GHS Hazard statements
H300+H310+H330
Personal Protective Equipment
Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
GHS Precautionary statements
P260-P264-P280-P284-P301+P310-P302+P350
GHS Signal Word
Danger
Risk Statements
26/27/28
Hazard Class
6.1
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), categories 1,2,3
MSDS Link
RID/ADR
UN 3382 6.1/PG 1
Storage Temperature
2-8°C
UN Number
3382
Safety Statements
36/37/39-45
RTECS
TE5075000
European Hazard Symbols
Highly toxic (T+)German water hazard class
3
Pharmacology Properties
Gene Information
human ... PTGS1(5742), PTGS2(5743)
Physical Property
Density
1.06 g/mL at 25 °C(lit.)
Boiling Point
62 °C/9 mmHg(lit.)
Vapor Pressure
0.58 mmHg ( 20 °C)
Melting Point
-82 °C(lit.)
Refractive Index
n20/D 1.385(lit.)
Product Information
Purity
≥97.0% (GC)
Linear Formula
[(CH3)2CHO]2POF
Molecule Details
Analysis Note
Typically used at a concentration of 0.10 mM. A safer alternative inhibitor for serine protease is phenylmethylsulfonyl fluoride (PMSF).
Other Notes
Potent inhibitor of chymotrypsin and other enzymes (e.g. serine hydrolases)1; Inhibition of carboxypeptidase but not DAP I2
Biochem/physiol Actions
Potent inhibitor of serine proteases such as trypsin and chymotrypsin, and of acetylcholinesterase; also inhibits cathepsin G, cholinesterase, coagulation factor Xa, leucocyte elastase, pancreatic elastase, tissue kallikrein, plasmin, subtilisin, and thrombin. Inhibition of acetylcholinesterase makes this compound especially toxic. Inhibits apoptosis induced by ricin and bacterial toxins.
Typically used at a concentration of 0.10 mM. A safer alternative inhibitor for serine protease is phenylmethylsulfonyl fluoride (PMSF).
Other Notes
Potent inhibitor of chymotrypsin and other enzymes (e.g. serine hydrolases)1; Inhibition of carboxypeptidase but not DAP I2
Biochem/physiol Actions
Potent inhibitor of serine proteases such as trypsin and chymotrypsin, and of acetylcholinesterase; also inhibits cathepsin G, cholinesterase, coagulation factor Xa, leucocyte elastase, pancreatic elastase, tissue kallikrein, plasmin, subtilisin, and thrombin. Inhibition of acetylcholinesterase makes this compound especially toxic. Inhibits apoptosis induced by ricin and bacterial toxins.
Molecular Spectra
No Data Available
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References
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