Substance
ID:352042
Names and Identifiers
IUPAC name
5-(1,2-dithiolan-3-yl)pentanoic acid
IUPAC Traditional name
6,8-thioctic acid
Synonyms
Lip(S2)6,8-二巯基辛酸DL-α-硫辛酸(±)-α-硫辛酸DL-6,8-硫辛酸(±)-α-Lipoic acid(±)-1,2-二硫戊环基-3-戊酸6,8-Dithiooctanoic acidDL-α-Lipoic acid(±)-1,2-Dithiolane-3-pentanoic acidDL-6,8-Thioctic acid
Registration numbers
Beilstein Number
EC Number
CAS Number
MDL Number
PubChem SID
Properties
Safety Information
GHS Hazard statements
H302
Storage Temperature
2-8°C
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
GHS Signal Word
Warning
MSDS Link
Risk Statements
22
German water hazard class
3
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
European Hazard Symbols
Harmful (Xn)RTECS
JP1192000
Product Information
Purity
≥98.0% (HPLC)
≥98.0%
Empirical Formula (Hill Notation)
C8H14O2S2
Ignition Residue
≤0.1%
Loss on Drying
≤0.1% loss on drying, 20 °C (HV)
Pharmacology Properties
Gene Information
human ... ACHE(43), BCHE(590)rat ... Adra1a(29412), Adra1b(24173), Adra1d(29413)
Physical Property
Melting Point
60-62 °C
Molecule Details
Other Notes
Review1
Packaging
5, 25 g in glass bottle
Biochem/physiol Actions
Antioxidant and coenzyme needed for the activity of enzyme complexes such as those of pyruvate dehydrogenase and glycine decarboxylase. Exogenous thioctic acid is reduced intracellularly by two or more enzymes. The reduced form then influences a number of cell processes by direct radical scavenging, recycling of other antioxidants, increasing glutathione synthesis, and modulating transcription factor activity particularly that of NF-κB. Decreases the phagocytosis of myelin by macrophages.
Review1
Packaging
5, 25 g in glass bottle
Biochem/physiol Actions
Antioxidant and coenzyme needed for the activity of enzyme complexes such as those of pyruvate dehydrogenase and glycine decarboxylase. Exogenous thioctic acid is reduced intracellularly by two or more enzymes. The reduced form then influences a number of cell processes by direct radical scavenging, recycling of other antioxidants, increasing glutathione synthesis, and modulating transcription factor activity particularly that of NF-κB. Decreases the phagocytosis of myelin by macrophages.
Molecular Spectra
No Data Available
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References
No Data Available
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