Substance
ID:351775
Names and Identifiers
IUPAC name
6-bromo-5-(methylamino)-2-{[(2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(2S)-1-oxo-1-(1H-pyrrol-2-yl)propan-2-yl]-1,7-dioxaspiro[5.5]undecan-2-yl]methyl}-1,3-benzoxazole-4-carboxylic acid
Synonyms
4-Bromo-calcium Ionophore A231874-Bromo-A231874-Bromo-calcimycin
IUPAC Traditional name
6-bromo-5-(methylamino)-2-{[(2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(2S)-1-oxo-1-(1H-pyrrol-2-yl)propan-2-yl]-1,7-dioxaspiro[5.5]undecan-2-yl]methyl}-1,3-benzoxazole-4-carboxylic acid
Properties
Product Information
Empirical Formula (Hill Notation)
C29H36BrN3O6
Purity
≥95.0% (N)
Safety Information
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
GHS Precautionary statements
P261-P280-P305+P351+P338
German water hazard class
3
GHS Signal Word
Warning
Risk Statements
20/21/22-36/37/38
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
Safety Statements
26-36/37
Storage Temperature
2-8°C
European Hazard Symbols
Harmful (Xn)GHS Hazard statements
H302-H312-H315-H319-H332-H335
MSDS Link
Physical Property
Solubility
ethanol: soluble20 mg/mL, clear, yellow
Molecule Details
Application
Nonfluorescent Ca2+ ionophore that can be used to calibrate the quantitation of cytoplasmic free Ca2+ with fluorescent probes.
Bromo-A23187, a nonfluorescent ionophore, has been used in photolysis of a caged-Ca2+ compound and in [Ca2+]i elevation protocols1. It can be used to calibrate the quantitation of cytoplasmic free Ca2+ with fluorescent probes.
Other Notes
In biological environment, bromo-A23187 has a higher selectivity for Ca2+ over Mg2+ than A231872
Biochem/physiol Actions
Ionophores disrupt transmembrane ion concentration gradients which are required for proper functioning and survival of microorganisms. An ionophore, such as Bromo-A23187, increases the permeability of biological membranes to calcium.
Nonfluorescent Ca2+ ionophore that can be used to calibrate the quantitation of cytoplasmic free Ca2+ with fluorescent probes.
Bromo-A23187, a nonfluorescent ionophore, has been used in photolysis of a caged-Ca2+ compound and in [Ca2+]i elevation protocols1. It can be used to calibrate the quantitation of cytoplasmic free Ca2+ with fluorescent probes.
Other Notes
In biological environment, bromo-A23187 has a higher selectivity for Ca2+ over Mg2+ than A231872
Biochem/physiol Actions
Ionophores disrupt transmembrane ion concentration gradients which are required for proper functioning and survival of microorganisms. An ionophore, such as Bromo-A23187, increases the permeability of biological membranes to calcium.
Molecular Spectra
No Data Available
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References
No Data Available
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