Substance
ID:351248
Names and Identifiers
IUPAC Traditional name
trimethoprim
IUPAC name
5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine
Synonyms
2,4-二氨基-5-(3,4,5-三甲氧基苄基)嘧啶甲氧苄啶Trimethoprim2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine
Registration numbers
Beilstein Number
CAS Number
EC Number
MDL Number
PubChem SID
Properties
Product Information
Quality
crystallized
Empirical Formula (Hill Notation)
C14H18N4O3
Purity
≥99.0% (HPLC)
Physical Property
Melting Point
199-203 °C
Solubility
chloroform/ethanol (1:1): soluble50 mg/mL, clear, colorless
Safety Information
Storage Temperature
2-8°C
MSDS Link
RTECS
UV8225000
German water hazard class
3
Personal Protective Equipment
Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Pharmacology Properties
Gene Information
human ... DHFRP1(573971), KCNH1(3756)rat ... Dhfr(24312)
Molecule Details
Application
Primarily used as an antibacterial agent. Dihydrofolate reductase inhibitor with selectivity for the prokaryote enzyme.
Trimethoprim is primarily used as an antibacterial agent. It is used in susceptibility studies of Mycobacterium tuberculosis 1 and mechanism of resistance studies in Haemophilus influenzae 2.
Biochem/physiol Actions
Inhibits the synthesis of tetrahydrofolate by procaryote specific dihydrofolate reductase (DHFR).
Trimethoprim is a dihydrofolate reductase inhibitor with selectivity for the prokaryote enzyme.
Other Notes
Specific inhibitor of formulation. Widely used in studies on dihydrofolate reductase3,4.
Primarily used as an antibacterial agent. Dihydrofolate reductase inhibitor with selectivity for the prokaryote enzyme.
Trimethoprim is primarily used as an antibacterial agent. It is used in susceptibility studies of Mycobacterium tuberculosis 1 and mechanism of resistance studies in Haemophilus influenzae 2.
Biochem/physiol Actions
Inhibits the synthesis of tetrahydrofolate by procaryote specific dihydrofolate reductase (DHFR).
Trimethoprim is a dihydrofolate reductase inhibitor with selectivity for the prokaryote enzyme.
Other Notes
Specific inhibitor of formulation. Widely used in studies on dihydrofolate reductase3,4.
Molecular Spectra
No Data Available
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References
No Data Available
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