Substance
ID:351133
Names and Identifiers
IUPAC Traditional name
tranilast
Synonyms
Rizaben2-[[3-(3,4-Dimethoxyphenyl)-1-oxo-2-propenyl]amino] benzoic acidN-(3,4-Dimethoxycinnamoyl)anthranilic acid3,4-DAASB-252218Tranilast
IUPAC name
2-[3-(3,4-dimethoxyphenyl)prop-2-enamido]benzoic acid
Properties
Physical Property
Melting Point
166.2-168.2 °C(lit.)
Solubility
DMSO: >10 mg/mL
H2O: insoluble
Apperance
white to beige powder
Safety Information
Storage Temperature
2-8°C
Risk Statements
22
Safety Statements
26-36
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
MSDS Link
European Hazard Symbols
Harmful (Xn)RTECS
DG8731000
GHS Signal Word
Warning
GHS Hazard statements
H302
German water hazard class
3
Product Information
Empirical Formula (Hill Notation)
C18H17NO5
Purity
≥98% (HPLC)
Pharmacology Properties
Gene Information
human ... VEGFA(7422), VEGFB(7423), VEGFC(7424)
Molecule Details
Biochem/physiol Actions
Tranilast is an anti-asthma drug, which inhibits LTC4 and PGE2 formation in stimulated monocytes, but does not inhibit cyclooxygenase or lipoxygenase activity; inhibits mast cell degranulation; inhibits VEGF-induced angiogenesis in vivo and also inhibits proliferation and tube formation of human endothelial cells in vitro. Tranilast may represent a new class of drugs for therapy to treat ongoing TH1-mediated autoimmune diseases.
Tranilast is an anti-asthma drug, which inhibits LTC4 and PGE2 formation in stimulated monocytes, but does not inhibit cyclooxygenase or lipoxygenase activity; inhibits mast cell degranulation; inhibits VEGF-induced angiogenesis in vivo and also inhibits proliferation and tube formation of human endothelial cells in vitro. Tranilast may represent a new class of drugs for therapy to treat ongoing TH1-mediated autoimmune diseases.
Molecular Spectra
No Data Available
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References
No Data Available
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