Substance
ID:351036
Names and Identifiers
Synonyms
9-Nitro-7,12-dihydroindolo-[3,2-d][1]benzazepin-6(5)-oneAlsterpaullone
IUPAC Traditional name
alsterpaullone
IUPAC name
14-nitro-8,18-diazatetracyclo[9.7.0.02,7.012,17]octadeca-1(11),2,4,6,12,14,16-heptaen-9-one
Properties
Safety Information
MSDS Link
Storage Temperature
2-8°C
GHS Signal Word
Warning
Risk Statements
36/37/38
GHS Hazard statements
H315-H319-H335
GHS Precautionary statements
P261-P305+P351+P338
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
European Hazard Symbols
Irritant (Xi)Safety Statements
26-36
German water hazard class
3
Storage Condition
desiccated
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Product Information
Purity
≥98% (HPLC)
Empirical Formula (Hill Notation)
C16H11N3O3
Pharmacology Properties
Gene Information
rat ... Gsk3b(84027)
Physical Property
Apperance
yellow to brown powder
Solubility
DMSO: ≥10 mg/mL
Molecule Details
Biochem/physiol Actions
Potent and selective inhibitor of GSK-3β and CDK5/p25; potent inhibitor of CDK1/cyclin B (IC50 = 0.035 μM).
Application
Alsterpaullone inhibits GSK-3β, CDK5/p25, and CDK1/cyclin B. Alsterpaullone has also been studied as an antimanic therapeutic for the acute manic phase of bipolar disorder.
Potent and selective inhibitor of GSK-3β and CDK5/p25; potent inhibitor of CDK1/cyclin B (IC50 = 0.035 μM).
Application
Alsterpaullone inhibits GSK-3β, CDK5/p25, and CDK1/cyclin B. Alsterpaullone has also been studied as an antimanic therapeutic for the acute manic phase of bipolar disorder.
Molecular Spectra
No Data Available
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References
No Data Available
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