Substance
ID:350796
Names and Identifiers
IUPAC Traditional name
2-{4-[2-(trifluoromethyl)phenyl]piperidine-1-carbonylamino}benzoic acid
IUPAC name
2-({4-[2-(trifluoromethyl)phenyl]piperidine-1-carbonyl}amino)benzoic acid
Synonyms
A11202-(4-(2-(trifluoromethyl)phenyl)piperidine-1-carboxamido)benzoic acid
Registration numbers
MDL Number
Properties
Physical Property
Apperance
off-white powder
Solubility
DMSO: ≥10 mg/mL
Safety Information
RID/ADR
UN 3077 9/PG 3
GHS Precautionary statements
P273-P280-P305+P351+P338
Risk Statements
22-36-43-50/53
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
Hazardous to the aquatic environment
Acute hazard, category1
Chronic hazard, categories 1,2
GHS Signal Word
Warning
European Hazard Symbols
Harmful (Xn)
Nature polluting (N)Safety Statements
26-36/37-60-61
UN Number
3077
German water hazard class
3
GHS Hazard statements
H302-H317-H319-H400
Storage Condition
desiccated
MSDS Link
Packing Group
3
Storage Temperature
2-8°C
Hazard Class
9
Product Information
Empirical Formula (Hill Notation)
C20H19F3N2O3
Purity
≥98% (HPLC)
Molecule Details
Biochem/physiol Actions
A1120 is a selective non-retinoid ligand for retinol-binding protein 4 (RBP4). RBP4 transports retinol from the liver to extrahepatic tissues and RBP4 lowering is reported to improve insulin sensitivity in mice. A1120 is a high affinity non-retinoid ligand for RBP4 which disrupts the interaction between RBP4 and its binding partner transthyretin (TTR). It binds to the same site as retinol and induces changes in the orientation (compared to the retinol bound form) of loops at the RBP4-TTR interaction interface.A1120 lowers RBP4 and retinol levels in a dose-dependent manner, to a similar extent as seen with fenretinide. However, unlike fenretinide (Sigma# H7779), A1120 does not have beneficial effects on insulin resistance.
A1120 is a selective non-retinoid ligand for retinol-binding protein 4 (RBP4). RBP4 transports retinol from the liver to extrahepatic tissues and RBP4 lowering is reported to improve insulin sensitivity in mice. A1120 is a high affinity non-retinoid ligand for RBP4 which disrupts the interaction between RBP4 and its binding partner transthyretin (TTR). It binds to the same site as retinol and induces changes in the orientation (compared to the retinol bound form) of loops at the RBP4-TTR interaction interface.A1120 lowers RBP4 and retinol levels in a dose-dependent manner, to a similar extent as seen with fenretinide. However, unlike fenretinide (Sigma# H7779), A1120 does not have beneficial effects on insulin resistance.
Molecular Spectra
No Data Available
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References
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