Substance
ID:350769
Names and Identifiers
IUPAC name
benzyl N-{[(2R,4S,7R)-6,11-dimethyl-6,11-diazatetracyclo[7.6.1.02,7.012,16]hexadeca-1(16),9,12,14-tetraen-4-yl]methyl}carbamate
IUPAC Traditional name
metergoline
Synonyms
N-CBZ-[(8β)-1,6-Dimethylergolin-8-yl]methylamine[(8β)-1,6-Dimethylergolin-8-yl)methyl]carbamic acid phenylmethyl esterMetergoline
Properties
Safety Information
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
GHS Precautionary statements
P280
Risk Statements
20/21/22
German water hazard class
3
GHS Signal Word
Warning
RTECS
FA1070000
Storage Temperature
-20°C
MSDS Link
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
GHS Hazard statements
H302-H312-H332
European Hazard Symbols
Harmful (Xn)Safety Statements
36
Physical Property
Melting Point
148-150 °C(lit.)
Solubility
0.1 M HCl: soluble1.4 mg/mL
ethanol: soluble4 mg/mL
H2O: insoluble
Pharmacology Properties
Gene Information
human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR7(3363)rat ... Htr7(65032)
Product Information
Empirical Formula (Hill Notation)
C25H29N3O2
Molecule Details
Biochem/physiol Actions
Antagonist at 5-HT1, 5-HT2, and 5-HT7 serotonin receptors; analgesic; antipyretic.
Antagonist at 5-HT1, 5-HT2, and 5-HT7 serotonin receptors; analgesic; antipyretic.
Molecular Spectra
No Data Available
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References
No Data Available
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