Substance
ID:350608
Names and Identifiers
IUPAC name
({2-[(3-aminopropyl)amino]ethyl}sulfanyl)phosphonic acid
IUPAC Traditional name
amifostine
Synonyms
AmifostineWR27212-(3-Aminopropyl)aminoethyl phosphorothioate
Properties
Safety Information
Safety Statements
26-36
GHS Hazard statements
H302
MSDS Link
Risk Statements
22
German water hazard class
3
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
Storage Temperature
2-8°C
RTECS
TE6491000
GHS Signal Word
Warning
European Hazard Symbols
Harmful (Xn)Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Product Information
Empirical Formula (Hill Notation)
C5H15N2O3PS
Purity
≥97% (TLC)
Physical Property
Apperance
powder
Molecule Details
Application
Amifostine may provide renal protection during PRRT using somatostatin analogs by mitigating radiation damage and reducing the absorbed kidney radiation dose. Amifostine remediates the degenerative effects of radiation on the mineralization capacity of the murine mandible.
Biochem/physiol Actions
Radioprotective agent. Selectively protects normal tissues from the damaging effects of anti-neoplastic radiation therapy. Selectivity is due to preferential uptake by normal tissues and subsequent metabolic activation to 2-(3-aminopropyl)aminoethanethiol.
Amifostine may provide renal protection during PRRT using somatostatin analogs by mitigating radiation damage and reducing the absorbed kidney radiation dose. Amifostine remediates the degenerative effects of radiation on the mineralization capacity of the murine mandible.
Biochem/physiol Actions
Radioprotective agent. Selectively protects normal tissues from the damaging effects of anti-neoplastic radiation therapy. Selectivity is due to preferential uptake by normal tissues and subsequent metabolic activation to 2-(3-aminopropyl)aminoethanethiol.
Molecular Spectra
No Data Available
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References
No Data Available
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