Substance
ID:350515
Names and Identifiers
IUPAC Traditional name
colchicine
Synonyms
秋水仙素Colchicine
IUPAC name
N-[(10S)-3,4,5,14-tetramethoxy-13-oxotricyclo[9.5.0.02,7]hexadeca-1(16),2,4,6,11,14-hexaen-10-yl]acetamide
Registration numbers
CAS Number
Beilstein Number
EC Number
MDL Number
PubChem SID
Properties
Safety Information
European Hazard Symbols
Highly toxic (T+)RTECS
GH0700000
UN Number
1544
GHS Pictograms
Corrosive to metals, category 1
Skin corrosion, categories 1A,1B,1C
Serious eye damage, category 1
Acute toxicity (oral, dermal, inhalation), categories 1,2,3
Respiratory sensitization, category 1
Germ cell mutagenicity, categories 1A,1B,2
Carcinogenicity, categories 1A,1B,2
Reproductive toxicity, categories 1A,1B,2
Specific Target Organ Toxicity – Single exposure, categories 1,2
Specific Target Organ Toxicity – Repeated exposure, categories 1,2
Aspiration Hazard, category 1
GHS Signal Word
Danger
RID/ADR
UN 1544 6.1/PG 1
Safety Statements
53-45
GHS Hazard statements
H300+H330-H318-H340
Packing Group
1
GHS Precautionary statements
P201-P260-P264-P280-P284-P301+P310
Personal Protective Equipment
Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Hazard Class
6.1
Risk Statements
46-28
German water hazard class
3
MSDS Link
Physical Property
Apperance
white to yellow powder
Solubility
ethanol: soluble50 mg/mL
Melting Point
150-160 °C (dec.)(lit.)
Product Information
Purity
≥95% (HPLC)
Empirical Formula (Hill Notation)
C22H25NO6
Pharmacology Properties
Gene Information
human ... ABCB1(5243), CYP3A4(1576)mouse ... Abcb1a(18671), Abcb1b(18669)
Molecule Details
Packaging
1, 5 g in poly bottle
100, 500 mg in poly bottle
Biochem/physiol Actions
Antimitotic agent that disrupts microtubules by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.
1, 5 g in poly bottle
100, 500 mg in poly bottle
Biochem/physiol Actions
Antimitotic agent that disrupts microtubules by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.
Molecular Spectra
No Data Available
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References
No Data Available
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