Substance
ID:350514
Names and Identifiers
IUPAC Traditional name
colchicine
Synonyms
秋水仙素Colchicine
IUPAC name
N-[(10S)-3,4,5,14-tetramethoxy-13-oxotricyclo[9.5.0.02,7]hexadeca-1(16),2,4,6,11,14-hexaen-10-yl]acetamide
Registration numbers
CAS Number
Beilstein Number
PubChem SID
EC Number
MDL Number
Properties
Safety Information
GHS Pictograms
Corrosive to metals, category 1
Skin corrosion, categories 1A,1B,1C
Serious eye damage, category 1
Respiratory sensitization, category 1
Germ cell mutagenicity, categories 1A,1B,2
Carcinogenicity, categories 1A,1B,2
Reproductive toxicity, categories 1A,1B,2
Specific Target Organ Toxicity – Single exposure, categories 1,2
Specific Target Organ Toxicity – Repeated exposure, categories 1,2
Aspiration Hazard, category 1
Acute toxicity (oral, dermal, inhalation), categories 1,2,3
European Hazard Symbols
Highly toxic (T+)Personal Protective Equipment
Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Safety Statements
53-45
MSDS Link
RID/ADR
UN 1544 6.1/PG 1
Risk Statements
46-28
RTECS
GH0700000
GHS Signal Word
Danger
UN Number
1544
GHS Hazard statements
H300+H330-H318-H340
Hazard Class
6.1
German water hazard class
3
GHS Precautionary statements
P201-P260-P264-P280-P284-P301+P310
Packing Group
1
Pharmacology Properties
Gene Information
human ... ABCB1(5243), CYP3A4(1576)mouse ... Abcb1a(18671), Abcb1b(18669)
Product Information
Product Line
BioReagent
Purity
≥95% (HPLC)
Empirical Formula (Hill Notation)
C22H25NO6
Suitability
plant cell culture tested
Physical Property
Melting Point
150-160 °C (dec.)(lit.)
Molecule Details
Biochem/physiol Actions
Colchicine is an inhibitor of microtubule polymerization which blocks chromosome segregation during meiosis. Consequently, Colchicine is used to induce polyploidy (tetraploid) in plant cells.
Colchicine is an inhibitor of microtubule polymerization which blocks chromosome segregation during meiosis. Consequently, Colchicine is used to induce polyploidy (tetraploid) in plant cells.
Molecular Spectra
No Data Available
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References
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