Substance
ID:350440
Names and Identifiers
IUPAC name
3-{1-[3-(dimethylamino)propyl]-1H-indol-3-yl}-4-(1H-indol-3-yl)-2,5-dihydro-1H-pyrrole-2,5-dione
Synonyms
3-[1-[3-(Dimethylamino)propyl]1H-indol-3-yl]-4-(1Hindol-3-yl)1H-pyrrole-2,5dione3-(N-[Dimethylamino]propyl-3-indolyl)-4-(3-indolyl)maleimideBisindolylmaleimide IGF 109203X
IUPAC Traditional name
bisindolylmaleimide
Properties
Safety Information
MSDS Link
German water hazard class
3
Risk Statements
40
Storage Temperature
2-8°C
European Hazard Symbols
Harmful (Xn)Safety Statements
36/37
Product Information
Purity
≥90% (HPLC)
Biological Source
synthetic
Empirical Formula (Hill Notation)
C25H24N4O2
Physical Property
Solubility
DMSO: soluble (~1 mg/ml)
Molecule Details
Biochem/physiol Actions
A potent and selective competitive inhibitor of protein kinase C (PKC) and of glycogen synthase kinase-3 (GSK-3). In certain cells, inhibition of PKC leads to an increase in autophagy. For PKC inhibition, typically used at a concentration of 0.1-10 μM.
A potent and selective competitive inhibitor of protein kinase C (PKC) and of glycogen synthase kinase-3 (GSK-3). Inhibits parathyroid hormone-induced Ca2+ resorption from isolated bone tissue, Staurosporine, another protein kinase inhibitor, actually enhanced Ca2+ resorption elicited by a number of agents, but GF109203X counteracted that enhancement.1
Quantity
For PKC inhibition, typically used at a concentration of 0.1-10 μM.
A potent and selective competitive inhibitor of protein kinase C (PKC) and of glycogen synthase kinase-3 (GSK-3). In certain cells, inhibition of PKC leads to an increase in autophagy. For PKC inhibition, typically used at a concentration of 0.1-10 μM.
A potent and selective competitive inhibitor of protein kinase C (PKC) and of glycogen synthase kinase-3 (GSK-3). Inhibits parathyroid hormone-induced Ca2+ resorption from isolated bone tissue, Staurosporine, another protein kinase inhibitor, actually enhanced Ca2+ resorption elicited by a number of agents, but GF109203X counteracted that enhancement.1
Quantity
For PKC inhibition, typically used at a concentration of 0.1-10 μM.
Molecular Spectra
No Data Available
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References
No Data Available
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