Substance
ID:350298
Names and Identifiers
IUPAC name
5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide
IUPAC Traditional name
leflunomide
Synonyms
5-Methylisoxazole-4-(4-trifluoromethyl)carboxanilideLeflunomide
Properties
Product Information
Empirical Formula (Hill Notation)
C12H9F3N2O2
Safety Information
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), categories 1,2,3
GHS Signal Word
Danger
GHS Hazard statements
H301-H315-H319-H335
Safety Statements
26
UN Number
2811
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
European Hazard Symbols
Harmful (Xn)RID/ADR
UN 2811 6.1/PG 3
RTECS
NY2354200
Storage Temperature
2-8°C
Hazard Class
6.1
Risk Statements
22-36/37/38
GHS Precautionary statements
P261-P301+P310-P305+P351+P338
German water hazard class
3
MSDS Link
Packing Group
3
Pharmacology Properties
Gene Information
human ... DHODH(1723)
Molecule Details
Biochem/physiol Actions
Immunosuppressive; inhibits T and B cell proliferation. Activity is attributed mainly to its metabolite, a malononitrile derivative, which is believed to inhibit dihydroorotate dehydrogenase (in the de novo pyrimidine synthesis pathway) as well as several protein tyrosine kinases.
Application
By virtue of its immunosuppressant effects, leflunomide has found use in organ transplantation1 and treatment of rheumatoid arthritis2 and other autoimmune diseases.
Immunosuppressive; inhibits T and B cell proliferation. Activity is attributed mainly to its metabolite, a malononitrile derivative, which is believed to inhibit dihydroorotate dehydrogenase (in the de novo pyrimidine synthesis pathway) as well as several protein tyrosine kinases.
Application
By virtue of its immunosuppressant effects, leflunomide has found use in organ transplantation1 and treatment of rheumatoid arthritis2 and other autoimmune diseases.
Molecular Spectra
No Data Available
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References
No Data Available
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