Substance
ID:350085
Names and Identifiers
IUPAC name
(2S)-2-[(2S)-2-acetamido-4-methylpentanamido]-4-methyl-N-[(2S)-1-oxohexan-2-yl]pentanamide
Synonyms
Calpain Inhibitor IALLNN-Acetyl-Leu-Leu-Norleu-alN-Acetyl-L-leucyl-L-leucyl-L-norleucinalAc-LLnL-CHOMG-101
IUPAC Traditional name
(2S)-2-[(2S)-2-acetamido-4-methylpentanamido]-4-methyl-N-[(2S)-1-oxohexan-2-yl]pentanamide
Registration numbers
CAS Number
Beilstein Number
MDL Number
PubChem SID
Properties
Physical Property
Solubility
DMSO: soluble
ethanol: soluble
Apperance
white powder
Safety Information
Storage Temperature
-20°C
German water hazard class
3
MSDS Link
Personal Protective Equipment
Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Product Information
Purity
≥97% (TLC)
Empirical Formula (Hill Notation)
C20H37N3O4
Pharmacology Properties
Gene Information
human ... CAPN1(823), CTSB(1508), PSMA1(5682)
Molecule Details
Application
Calpain inhibitor I reversibly blocks the calcium-dependent neutral cysteine protease calpain I. Calpains have been implicated in various cellular processes, including cell proliferation, apoptosis, and cell differentiation.
Biochem/physiol Actions
Can initiate apoptosis in HL-60 cells1 but blocks dexamethasone-induced apoptosis in thymocytes and cycloheximide-induced apoptosis in metamyelocytes.2 Inhibits cyclin B degradation and arrests the cell cycle at G1/S and at meta-/anaphase.3 Blocks induction of nitric oxide synthase by LPS in macrophages.4
Calpain inhibitor I reversibly blocks the calcium-dependent neutral cysteine protease calpain I. Calpains have been implicated in various cellular processes, including cell proliferation, apoptosis, and cell differentiation.
Biochem/physiol Actions
Can initiate apoptosis in HL-60 cells1 but blocks dexamethasone-induced apoptosis in thymocytes and cycloheximide-induced apoptosis in metamyelocytes.2 Inhibits cyclin B degradation and arrests the cell cycle at G1/S and at meta-/anaphase.3 Blocks induction of nitric oxide synthase by LPS in macrophages.4
Molecular Spectra
No Data Available
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References
No Data Available
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