Substance
ID:350011
Names and Identifiers
IUPAC name
(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-dodecahydro-1H-naphtho[2,1-b]pyran-5-yl acetate
IUPAC Traditional name
forskolin
Synonyms
Coleonol7β-Acetoxy-8,13-epoxy-1α,6β,9α-trihydroxylabd-14-en-11-oneForskolinColforsin
Registration numbers
CAS Number
MDL Number
EC Number
Beilstein Number
PubChem SID
Properties
Safety Information
European Hazard Symbols
Harmful (Xn)GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
GHS Signal Word
Warning
GHS Hazard statements
H312
GHS Precautionary statements
P280
Safety Statements
22-36/37
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
RTECS
QL6150000
MSDS Link
German water hazard class
3
Risk Statements
21
Product Information
Biological Source
from Coleus forskohlii
Empirical Formula (Hill Notation)
C22H34O7
Purity
≥98% (HPLC)
Pharmacology Properties
Gene Information
human ... OPRK1(4986), SLC2A10(81031), TNF(7124)
Physical Property
Solubility
DMSO: soluble5 mg/mL (stable at least 6 months at room temperature)
ethanol: soluble
Apperance
off-white powder
Molecule Details
Biochem/physiol Actions
Cell-permeable diterpenoid that possesses anti-hypertensive, positive inotropic, and adenylyl cyclase activating properties. Many of its biological effects are due to its activation of adenylyl cyclase and the resulting increase in intracellular cAMP concentration.1 Forskolin effects calcium currents and inhibits MAP kinase.
Cell-permeable diterpenoid that possesses anti-hypertensive, positive inotropic, and adenylyl cyclase activating properties. Many of its biological effects are due to its activation of adenylyl cyclase and the resulting increase in intracellular cAMP concentration.1 Forskolin effects calcium currents and inhibits MAP kinase.
Molecular Spectra
No Data Available
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References
No Data Available
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