Substance
ID:349897
Names and Identifiers
IUPAC name
7-chloro-5-(4-chlorophenyl)-1-methyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one
IUPAC Traditional name
4-chlorodiazepam
Synonyms
4′-ChlorodiazepamRo 5-4864Ro5-48647-Chloro-5-(4-chlorophenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one
Registration numbers
CAS Number
Beilstein Number
MDL Number
PubChem SID
Properties
Product Information
Purity
≥98% (TLC)
Empirical Formula (Hill Notation)
C16H12Cl2N2O
Physical Property
Solubility
H2O: insoluble
2-hydroxypropyl-β-cyclodextrin: insoluble
Safety Information
GHS Hazard statements
H302
European Hazard Symbols
Harmful (Xn)Risk Statements
22
Safety Statements
22-24/25
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
MSDS Link
German water hazard class
3
RTECS
DF0500000
Drug Control
regulated under CDSA - not available from Sigma-Aldrich Canada
GHS Signal Word
Warning
Pharmacology Properties
Gene Information
rat ... Tspo(24230)
Molecule Details
Application
Peripheral benzodiazepine ligand useful in distinguishing central-type from peripheral-type benzodiazepine receptors.
Biochem/physiol Actions
4′-Chlorodiazepam (Ro5-4864) is a potent selective antagonist of the mitochondrial translocator protein 18kDa (TSPO), formerly known as the peripheral benzodiazepine receptor (PBR). Ro5-4864 does not bind to GABA(A) receptors and lacks typical benzodiazepine effects, but has been found to be neuroprotective in several studies.
Peripheral benzodiazepine ligand useful in distinguishing central-type from peripheral-type benzodiazepine receptors.
Biochem/physiol Actions
4′-Chlorodiazepam (Ro5-4864) is a potent selective antagonist of the mitochondrial translocator protein 18kDa (TSPO), formerly known as the peripheral benzodiazepine receptor (PBR). Ro5-4864 does not bind to GABA(A) receptors and lacks typical benzodiazepine effects, but has been found to be neuroprotective in several studies.
Molecular Spectra
No Data Available
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References
No Data Available
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