Substance
ID:349562
Names and Identifiers
IUPAC name
4-[(4-cyanophenyl)(1H-1,2,4-triazol-1-yl)methyl]benzonitrile
IUPAC Traditional name
letrozole
Synonyms
4,4′-(1H-1,2,4-Triazol-1-ylmethylene)bisbenzonitrileLetrozole
Properties
Safety Information
Product Information
Purity
≥98% (HPLC)
Empirical Formula (Hill Notation)
C17H11N5
Physical Property
Apperance
white to off-white powder
Solubility
DMSO: >50 mg/mL
Molecule Details
Biochem/physiol Actions
Letrozole is a third generation nonsteroidal aromatase inhibitor. It is a competitive inhibitor of the aromatase enzyme system and thus inhibits the conversion of androgens to estrogens. Letrozole inhibits the aromatase enzyme by competitively binding to the heme of the cytochrome P450 subunit of the enzyme, resulting in a reduction of estrogen biosynthesis in all tissues.
Letrozole is a third generation nonsteroidal aromatase inhibitor. It is a competitive inhibitor of the aromatase enzyme system and thus inhibits the conversion of androgens to estrogens. Letrozole inhibits the aromatase enzyme by competitively binding to the heme of the cytochrome P450 subunit of the enzyme, resulting in a reduction of estrogen biosynthesis in all tissues.
Molecular Spectra
No Data Available
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References
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