Substance
ID:349511
Names and Identifiers
IUPAC name
N-[2-(7-methoxynaphthalen-1-yl)ethyl]acetamide
IUPAC Traditional name
agomelatine
Synonyms
S-20098N-[2-(7-Methoxy-1-naphthalenyl)ethyl]-acetamideAgomelatine
Properties
Product Information
Purity
≥98% (HPLC)
Empirical Formula (Hill Notation)
C15H17NO2
Safety Information
German water hazard class
3
MSDS Link
GHS Hazard statements
H400
GHS Precautionary statements
P273
Safety Statements
61
GHS Signal Word
Warning
European Hazard Symbols
Nature polluting (N)Risk Statements
50
GHS Pictograms
Hazardous to the aquatic environment
Acute hazard, category1
Chronic hazard, categories 1,2
Storage Temperature
2-8°C
Physical Property
Apperance
white to off-white powder
Solubility
DMSO: >50 mg/mL
Molecule Details
Biochem/physiol Actions
Agomelatine is an extremely potent agonist at both melatonin receptors (MT1 and MT2), with additional antagonism at 5HT2C. It is a novel antidepressant with many desired in vivo properties, including neuroprotection and neurogenesis in depression-sensitive brain areas. Agomelatine′s efficacy appears to be due to both melatonergic and serotonergic properties. In neurogenesis assays, both in vitro and in vivo, the compound effects were differentially affected by antagonists for MT1/MT2 and 5HT2C, demonstrating actions through all three receptors.
Agomelatine is an extremely potent agonist at both melatonin receptors (MT1 and MT2), with additional antagonism at 5HT2C. It is a novel antidepressant with many desired in vivo properties, including neuroprotection and neurogenesis in depression-sensitive brain areas. Agomelatine′s efficacy appears to be due to both melatonergic and serotonergic properties. In neurogenesis assays, both in vitro and in vivo, the compound effects were differentially affected by antagonists for MT1/MT2 and 5HT2C, demonstrating actions through all three receptors.
Molecular Spectra
No Data Available
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References
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