Substance
ID:349428
Names and Identifiers
IUPAC name
2-[(acetyloxy)methyl]-4-(2-amino-9H-purin-9-yl)butyl acetate
IUPAC Traditional name
famciclovir
Synonyms
BRL 428102-(2-(2-Amino-9H-purin-9-yl)ethyl)-1,3-propanediol diacetate esterFamciclovir
Properties
Physical Property
Solubility
DMSO: ≥10 mg/mL
Apperance
solid
Safety Information
RTECS
TY3164000
MSDS Link
Storage Temperature
2-8°C
German water hazard class
3
Storage Condition
desiccated
Product Information
Empirical Formula (Hill Notation)
C14H19N5O4
Purity
≥98% (HPLC)
Molecule Details
Biochem/physiol Actions
Famciclovir is an antiretroviral guanosine analog used to treat herpesvirus infections and hepatitis B. Famciclovir is rapidly converted to penciclovir. Viral thymidine kinase phosphorylates penciclovir to a monophosphate form that celular kinases convert in turn to penciclovir triphosphate. Penciclovir triphosphate competitively inhibits viral DNA polymerase and thus viral replication. Prolonged administration can lead to resistance; it is often manifested as selection of pre-existing resistant strains with mutations in the reverse transcriptase domain of the DNA polymerase gene.1
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. F7932.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
Famciclovir is an antiretroviral guanosine analog used to treat herpesvirus infections and hepatitis B. Famciclovir is rapidly converted to penciclovir. Viral thymidine kinase phosphorylates penciclovir to a monophosphate form that celular kinases convert in turn to penciclovir triphosphate. Penciclovir triphosphate competitively inhibits viral DNA polymerase and thus viral replication. Prolonged administration can lead to resistance; it is often manifested as selection of pre-existing resistant strains with mutations in the reverse transcriptase domain of the DNA polymerase gene.1
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. F7932.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
Molecular Spectra
No Data Available
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References
No Data Available
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