Substance
ID:349306
Names and Identifiers
IUPAC Traditional name
exemestane
Synonyms
Exemestane6-Methyleneandrosta-1,4-diene-3,17-dione
IUPAC name
(1S,2R,10R,11S,15S)-2,15-dimethyl-8-methylidenetetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-diene-5,14-dione
Properties
Physical Property
Apperance
white to off-white powder
Optical Rotation
[α]/D +250 to +300°, c = 1 in methanol
Solubility
DMSO: ≥20 mg/mL
Safety Information
GHS Precautionary statements
P201-P305+P351+P338-P308+P313
Storage Temperature
room temp
German water hazard class
3
European Hazard Symbols
Nature polluting (N)
Toxic (T)MSDS Link
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
Respiratory sensitization, category 1
Germ cell mutagenicity, categories 1A,1B,2
Carcinogenicity, categories 1A,1B,2
Reproductive toxicity, categories 1A,1B,2
Specific Target Organ Toxicity – Single exposure, categories 1,2
Specific Target Organ Toxicity – Repeated exposure, categories 1,2
Aspiration Hazard, category 1
GHS Signal Word
Danger
Risk Statements
60-61-51
GHS Hazard statements
H319-H360
Safety Statements
53-22-36/37-57
Product Information
Empirical Formula (Hill Notation)
C20H24O2
Purity
≥98% (HPLC)
Molecule Details
Legal Information
Sold for research purposes under agreement from Pfizer Inc.
Biochem/physiol Actions
Exemestane is a steroidal antiestrogen and irreversible aromatase inhibitor. Exemestane acts as a false substrate for the aromatase enzyme. Exemestane also prevents the conversion of androgens to estrogens and is used to treat estrogen-dependent breast cancer.
Sold for research purposes under agreement from Pfizer Inc.
Biochem/physiol Actions
Exemestane is a steroidal antiestrogen and irreversible aromatase inhibitor. Exemestane acts as a false substrate for the aromatase enzyme. Exemestane also prevents the conversion of androgens to estrogens and is used to treat estrogen-dependent breast cancer.
Molecular Spectra
No Data Available
Click here to submit data
References
No Data Available
Click here to submit data