Substance
ID:349277
Names and Identifiers
IUPAC Traditional name
N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide
IUPAC name
N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide
Synonyms
N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-benzamidePD 0325901
Properties
Product Information
Purity
≥98% (HPLC)
Empirical Formula (Hill Notation)
C16H14F3IN2O4
Safety Information
GHS Pictograms
Respiratory sensitization, category 1
Germ cell mutagenicity, categories 1A,1B,2
Carcinogenicity, categories 1A,1B,2
Reproductive toxicity, categories 1A,1B,2
Specific Target Organ Toxicity – Single exposure, categories 1,2
Specific Target Organ Toxicity – Repeated exposure, categories 1,2
Aspiration Hazard, category 1
Acute toxicity (oral, dermal, inhalation), categories 1,2,3
Hazardous to the aquatic environment
Acute hazard, category1
Chronic hazard, categories 1,2
MSDS Link
GHS Precautionary statements
P273-P301+P310-P501
GHS Hazard statements
H301-H373-H410
European Hazard Symbols
Nature polluting (N)
Toxic (T)Storage Temperature
2-8°C
Risk Statements
25-48-50
Safety Statements
22-36/37/39-61
GHS Signal Word
Danger
German water hazard class
3
Physical Property
Optical Rotation
[α]/D -1.8 to -3.0°, c = 1 mg/mL in methanol
Apperance
white to off-white powder
Solubility
DMSO: ≥20 mg/mL
Molecule Details
Legal Information
Sold for research purposes under agreement from Pfizer Inc.
Biochem/physiol Actions
PD 0325901 is a potent MKK1 (MEK1) and MKK2 (MEK2) inhibitor. The Ki is 1.1 and 0.79 nM for MEK1 and MEK2, respectively. PD 0325901 was inactive against a panel of 27 other kinases. PD 0325901 inhibited C26 tumor pERK by 75% when dosed at 25 mg/kg in mice.
Sold for research purposes under agreement from Pfizer Inc.
Biochem/physiol Actions
PD 0325901 is a potent MKK1 (MEK1) and MKK2 (MEK2) inhibitor. The Ki is 1.1 and 0.79 nM for MEK1 and MEK2, respectively. PD 0325901 was inactive against a panel of 27 other kinases. PD 0325901 inhibited C26 tumor pERK by 75% when dosed at 25 mg/kg in mice.
Molecular Spectra
No Data Available
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References
No Data Available
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