Substance
ID:349220
Names and Identifiers
Synonyms
Tanshinone cCryptotanshinoneCryptotanshinon1,2,6,7,8,9-hexahydro-1,6,6-trimethyl- (R)-phenanthro(1,2-b)furan-10,11-dione
IUPAC name
(14R)-6,6,14-trimethyl-12-oxatetracyclo[8.7.0.02,7.011,15]heptadeca-1(10),2(7),8,11(15)-tetraene-16,17-dione
IUPAC Traditional name
(14R)-6,6,14-trimethyl-12-oxatetracyclo[8.7.0.02,7.011,15]heptadeca-1(10),2(7),8,11(15)-tetraene-16,17-dione
Properties
Product Information
Purity
≥98% (HPLC)
Empirical Formula (Hill Notation)
C19H20O3
Safety Information
RID/ADR
UN 2811 6.1/PG 3
European Hazard Symbols
Nature polluting (N)
Toxic (T)Storage Condition
desiccated
protect from light
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), categories 1,2,3
Hazardous to the aquatic environment
Acute hazard, category1
Chronic hazard, categories 1,2
Packing Group
3
German water hazard class
3
Risk Statements
25-50/53
Storage Temperature
2-8°C
GHS Signal Word
Danger
GHS Precautionary statements
P273-P301+P310-P501
GHS Hazard statements
H301-H410
Safety Statements
45-60-61
Hazard Class
6.1
UN Number
2811
MSDS Link
Physical Property
Solubility
DMSO: ≥5 mg/mL
Apperance
orange-brown powder
Molecule Details
Biochem/physiol Actions
Cryptotanshinone is a quinoid diterpene isolated from the root of the Asian medicinal plant, Salvia miotiorrhiza bunge. Recently it was discovered that the compound is a potent STAT3 inhibitor. Cryptotanshinone rapidly inhibited STAT3 Tyr705 phosphorylation through a JAK2-independent mechanism. Cryptotanshinone selectively inhibits STAT3-activated cell lines through binding to monomer STAT3, subsequently blocking the dimerization and inhibiting STAT3 transcriptional regulatory activity. Previously, it was reported that the compound counteracts inflammation through the inhibition of cyclooxygenase II activity and endothelin-1 expression. In traditional oriental medicine dried roots of Salvia Miltiorrhiza Bunge (Danshen) have commonly been used for the treatment of circulatory disorders, liver disease, coronary heart disease, hepatitis, and chronic renal failure.
Cryptotanshinone is a quinoid diterpene isolated from the root of the Asian medicinal plant, Salvia miotiorrhiza bunge. Recently it was discovered that the compound is a potent STAT3 inhibitor. Cryptotanshinone rapidly inhibited STAT3 Tyr705 phosphorylation through a JAK2-independent mechanism. Cryptotanshinone selectively inhibits STAT3-activated cell lines through binding to monomer STAT3, subsequently blocking the dimerization and inhibiting STAT3 transcriptional regulatory activity. Previously, it was reported that the compound counteracts inflammation through the inhibition of cyclooxygenase II activity and endothelin-1 expression. In traditional oriental medicine dried roots of Salvia Miltiorrhiza Bunge (Danshen) have commonly been used for the treatment of circulatory disorders, liver disease, coronary heart disease, hepatitis, and chronic renal failure.
Molecular Spectra
No Data Available
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References
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