Substance
ID:349165
Names and Identifiers
IUPAC name
2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl acetate
IUPAC Traditional name
nitazoxanide
Synonyms
NitazoxanideNTZ; 2-(Acetyloxy)-N-(5-nitro-2-thiazolyl)benzamide
Properties
Safety Information
GHS Hazard statements
H302-H315-H319-H335
GHS Signal Word
Warning
Storage Temperature
2-8°C
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
GHS Precautionary statements
P261-P305+P351+P338
MSDS Link
German water hazard class
3
European Hazard Symbols
Harmful (Xn)Risk Statements
22-36/37/38
Safety Statements
26-36
Product Information
Purity
≥98% (HPLC)
Empirical Formula (Hill Notation)
C12H9N3O5S
Molecule Details
Biochem/physiol Actions
Nitazoxanide is an inhibitor of pyruvate-ferredoxin oxidoreductase (PFOR); Antimicrobial recently found to kill both non-replicating and replicating mycobacteria. FDA approved anti-parasitic drug (2002). Recent work (C & EN Sept. 14, 2009, p. 28) highlights that NTZ kills non-replicating and replicating TB bacteria and no apparent resistance is detected.
Nitazoxanide is an inhibitor of pyruvate-ferredoxin oxidoreductase (PFOR); Antimicrobial recently found to kill both non-replicating and replicating mycobacteria. FDA approved anti-parasitic drug (2002). Recent work (C & EN Sept. 14, 2009, p. 28) highlights that NTZ kills non-replicating and replicating TB bacteria and no apparent resistance is detected.
Molecular Spectra
No Data Available
Click here to submit data
References
No Data Available
Click here to submit data