Substance
ID:349089
Names and Identifiers
IUPAC Traditional name
naphtho[1,2-d][1,3]thiazol-2-amine
IUPAC name
naphtho[1,2-d][1,3]thiazol-2-amine
Synonyms
SKA-31Naphtho[1,2-d]thiazol-2-ylamine
Properties
Safety Information
Storage Temperature
-20°C
Safety Statements
26
European Hazard Symbols
Harmful (Xn)GHS Hazard statements
H302-H319
MSDS Link
GHS Precautionary statements
P305+P351+P338
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
Risk Statements
22-36
GHS Signal Word
Warning
Product Information
Empirical Formula (Hill Notation)
C11H8N2S
Purity
≥98% (HPLC)
Physical Property
Apperance
solid
Solubility
DMSO: ≥30 mg/mL
Molecule Details
Biochem/physiol Actions
SKA-31 is an activator of KCa2 and KCa3.1 calcium-activated potassium channels. Its EC50 is almost identical at 2-3 μM for all KCa2 subtypes, and about 10-fold lower (260 nM) at KCa3.1 channels. It has significant blood-pressure reducing activity in experimentally hypertensive mice,1 suggesting potassium channel activation as a therapeutic target for hypertension.
SKA31 is an activator of KCa2 and KCa3.1 Potassium Channels, Potentiates the EDHF Response and Lowers Blood Pressure.
SKA-31 is an activator of KCa2 and KCa3.1 calcium-activated potassium channels. Its EC50 is almost identical at 2-3 μM for all KCa2 subtypes, and about 10-fold lower (260 nM) at KCa3.1 channels. It has significant blood-pressure reducing activity in experimentally hypertensive mice,1 suggesting potassium channel activation as a therapeutic target for hypertension.
SKA31 is an activator of KCa2 and KCa3.1 Potassium Channels, Potentiates the EDHF Response and Lowers Blood Pressure.
Molecular Spectra
No Data Available
Click here to submit data
References
No Data Available
Click here to submit data