Substance
ID:349054
Names and Identifiers
IUPAC name
(2R,3S)-2-amino-3-methylpentanedioic acid
Synonyms
T3MG(±)-threo-3-Methylglutamic acid3MGthreo-3-Methylglutamate
IUPAC Traditional name
(3r)-3-methyl-L-glutamic acid
Properties
Safety Information
Safety Statements
26
European Hazard Symbols
Irritant (Xi)GHS Signal Word
Warning
Risk Statements
36/37/38
MSDS Link
German water hazard class
3
GHS Precautionary statements
P261-P305+P351+P338
Storage Temperature
room temp
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
GHS Hazard statements
H315-H319-H335
Product Information
Empirical Formula (Hill Notation)
C6H11NO4
Purity
(single spot, TLC)
Physical Property
Solubility
H2O: >1.5 mg/dL
Apperance
white to off-white powder
Molecule Details
Biochem/physiol Actions
T3MG is a selective inhibitor of excitatory amino acid transporters GLT-1, EAAT2, and EAAT4. T3MG has long been utilized as a gold standard in the study of general EAAT function. It has more recently been shown to be selective for EAAT2 and EAAT4 as compared to EAAT1 and EAAT3 in electrophysiology and glutamate/aspartate uptake assays. Although there are other EAAT2-selective compounds, this is the first tool with selectivity for EAAT4. T3MG is not a substrate for the transporters themselves, nor does it have activity at glutamate ion channels.
T3MG is a selective inhibitor of excitatory amino acid transporters GLT-1, EAAT2, and EAAT4. T3MG has long been utilized as a gold standard in the study of general EAAT function. It has more recently been shown to be selective for EAAT2 and EAAT4 as compared to EAAT1 and EAAT3 in electrophysiology and glutamate/aspartate uptake assays. Although there are other EAAT2-selective compounds, this is the first tool with selectivity for EAAT4. T3MG is not a substrate for the transporters themselves, nor does it have activity at glutamate ion channels.
Molecular Spectra
No Data Available
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References
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