Substance
ID:349046
Names and Identifiers
IUPAC Traditional name
lamivudine
IUPAC name
4-amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-1,2-dihydropyrimidin-2-one
Synonyms
3TCHeptovirEpivirEpivir-HBVZeffixLamivudine2′,3′-Dideoxy-3′-thiacytidine
Properties
Product Information
Purity
≥98% (HPLC)
Empirical Formula (Hill Notation)
C8H11N3O3S
Safety Information
GHS Hazard statements
H315-H319-H335
European Hazard Symbols
Irritant (Xi)GHS Precautionary statements
P261-P305+P351+P338
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
GHS Signal Word
Warning
MSDS Link
German water hazard class
3
Storage Temperature
room temp
Risk Statements
36/37/38
Safety Statements
26-36
Physical Property
Apperance
white to off-white powder
Solubility
DMSO: >20 mg/mL
Molecule Details
Biochem/physiol Actions
Lamivudine is a potent nucleoside analog reverse transcriptase inhibitor (nRTI). It is an analogue of cytidine, and can inhibit both types (1 and 2) of HIV reverse transcriptase as well as the reverse transcriptase of hepatitis B. It needs to be phosphorylated to its triphosphate form before it is active. 3TC-triphosphate also inhibits cellular DNA polymerase.
Lamivudine is a potent nucleoside analog reverse transcriptase inhibitor (nRTI). It is an analogue of cytidine, and can inhibit both types (1 and 2) of HIV reverse transcriptase as well as the reverse transcriptase of hepatitis B. It needs to be phosphorylated to its triphosphate form before it is active. 3TC-triphosphate also inhibits cellular DNA polymerase.
Molecular Spectra
No Data Available
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References
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