Substance
ID:348817
Names and Identifiers
IUPAC name
1-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]ethan-1-one
IUPAC Traditional name
(2R,4S)-ketoconazole
Synonyms
(±)-cis-1-Acetyl-4-(4-[(2-[2,4-dichlorophenyl]-2-[1H-imidazol-1-ylmethyl]-1,3-dioxolan-4-yl)-methoxy]phenyl)piperazineKetoconazole
Properties
Safety Information
European Hazard Symbols
Toxic (T)
Nature polluting (N)UN Number
2811
GHS Signal Word
Danger
Risk Statements
60-25-48/22-50/53
GHS Pictograms
Hazardous to the aquatic environment
Acute hazard, category1
Chronic hazard, categories 1,2
Respiratory sensitization, category 1
Germ cell mutagenicity, categories 1A,1B,2
Carcinogenicity, categories 1A,1B,2
Reproductive toxicity, categories 1A,1B,2
Specific Target Organ Toxicity – Single exposure, categories 1,2
Specific Target Organ Toxicity – Repeated exposure, categories 1,2
Aspiration Hazard, category 1
Acute toxicity (oral, dermal, inhalation), categories 1,2,3
Safety Statements
53-45-60-61
MSDS Link
RID/ADR
UN 2811 6.1/PG 3
GHS Hazard statements
H301-H360F-H373-H410
GHS Precautionary statements
P201-P273-P301+P310-P308+P313-P501
Storage Temperature
2-8°C
German water hazard class
3
Personal Protective Equipment
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
RTECS
TK7912300
Hazard Class
6.1
Packing Group
3
Pharmacology Properties
Gene Information
human ... ABCB1(5243), CYP11B1(1584), CYP11B2(1585), CYP17A1(1586), CYP19A1(1588), CYP1A2(1544), CYP24A1(1591), CYP26A1(1592), CYP3A4(1576), CYP51A1(1595), KCNH1(3756)mouse ... Abcb1a(18671), Abcb1b(18669)rat ... Alox5(25290), Cyp17a1(25146), Cyp51(25427), Cyp7a1(25428)
Product Information
Empirical Formula (Hill Notation)
C26H28Cl2N4O4
Physical Property
Apperance
white to light yellow
Molecule Details
Application
CYP3A4 inhibitor
Biochem/physiol Actions
Antifungal agent
CYP3A4 inhibitor
Biochem/physiol Actions
Antifungal agent
Molecular Spectra
No Data Available
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References
No Data Available
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