Substance
ID:348815
Names and Identifiers
IUPAC Traditional name
topotecan
Synonyms
SKF-104864A hydrochloride hydratehycamptamine hydrochloride hydrateNSC-609669 hydrochloride hydrateTopotecan hydrochloride hydrate9-[(dimethylamino)methyl]-10-hydroxy-(20S)-camptothecin hydrochloride hydrate
IUPAC name
(19S)-8-[(dimethylamino)methyl]-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione
Properties
Physical Property
Apperance
yellow powder
Solubility
DMSO: ≥20 mg/mL
Safety Information
GHS Pictograms
Respiratory sensitization, category 1
Germ cell mutagenicity, categories 1A,1B,2
Carcinogenicity, categories 1A,1B,2
Reproductive toxicity, categories 1A,1B,2
Specific Target Organ Toxicity – Single exposure, categories 1,2
Specific Target Organ Toxicity – Repeated exposure, categories 1,2
Aspiration Hazard, category 1
MSDS Link
Storage Condition
desiccated
protect from light
Storage Temperature
-20°C
GHS Hazard statements
H341
Risk Statements
46-48
Hazard Class
6.1
RID/ADR
UN 2811 6.1/PG 3
GHS Signal Word
Warning
GHS Precautionary statements
P281
Safety Statements
22-36
Packing Group
3
German water hazard class
3
UN Number
2811
Product Information
Empirical Formula (Hill Notation)
C23H23N3O5 · xHCl · yH2O
Purity
≥98% (HPLC and enzymatic)
Molecule Details
Biochem/physiol Actions
Topotecan is a topoisomerase I inhibitor and an apoptosis inducer. It is a potent antineoplastic agent.
Topotecan is a topoisomerase I inhibitor and an apoptosis inducer. It is a potent antineoplastic agent.
Molecular Spectra
No Data Available
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References
No Data Available
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