Substance
ID:348397
Names and Identifiers
IUPAC name
2-(4-benzylpiperazin-1-yl)-N'-{[2-hydroxy-3-(prop-2-en-1-yl)phenyl]methylidene}acetohydrazide
Synonyms
(4-Benzylpiperazino)acetic acid (3-allyl-2-hyroxybenzylidene)hydrazide1-Piperazineacetic acid, 2-(phenylmethyl)-,[[2-hydroxy-3-(2-propenyl)phenyl]methylene]hyrrazidePAC-1
IUPAC Traditional name
2-(4-benzylpiperazin-1-yl)-N'-{[2-hydroxy-3-(prop-2-en-1-yl)phenyl]methylidene}acetohydrazide
Properties
Product Information
Empirical Formula (Hill Notation)
C23H28N4O2
Purity
≥98% (HPLC)
Safety Information
GHS Precautionary statements
P261-P273-P305+P351+P338
Safety Statements
26-36/37-60-61
UN Number
3077
GHS Hazard statements
H302-H315-H319-H335-H400
RID/ADR
UN 3077 9/PG 3
GHS Pictograms
Hazardous to the aquatic environment
Acute hazard, category1
Chronic hazard, categories 1,2
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
MSDS Link
GHS Signal Word
Warning
Risk Statements
22-36/37/38-50/53
European Hazard Symbols
Harmful (Xn)
Nature polluting (N)Storage Temperature
room temp
Packing Group
3
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Hazard Class
9
German water hazard class
3
Physical Property
Solubility
DMSO: ≥10 mg/mL
deionized water: ≤2 mg/mL
Apperance
white solid
Molecule Details
Biochem/physiol Actions
PAC-1 is a caspase 3 activator. Caspase activation is a key strategy in cancer therapy. Caspase 3 is a key executioner caspase and direct effector of apoptosis. Hallmark of many cancers is the circumvention of signal in the activation of executioner caspases and loss of apoptotic response. EC50 for caspase 3 activation = 0.33 μM and caspase 7= 4.5 μM. The IC50 for apoptosis induction = 0.92 μM. Elevated caspase 3 level in cancerous cell lines and tissues allows PAC-1 to selectively induce apoptosis in tissues.
PAC-1 is a caspase 3 activator. Caspase activation is a key strategy in cancer therapy. Caspase 3 is a key executioner caspase and direct effector of apoptosis. Hallmark of many cancers is the circumvention of signal in the activation of executioner caspases and loss of apoptotic response. EC50 for caspase 3 activation = 0.33 μM and caspase 7= 4.5 μM. The IC50 for apoptosis induction = 0.92 μM. Elevated caspase 3 level in cancerous cell lines and tissues allows PAC-1 to selectively induce apoptosis in tissues.
Molecular Spectra
No Data Available
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References
No Data Available
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