Substance
ID:348389
Names and Identifiers
IUPAC name
2-methyl-1,2-bis(pyridin-3-yl)propan-1-one
IUPAC Traditional name
metyrapone
Synonyms
MetyraponeSu-4885美替拉酮2-甲基-1,2-二-3-吡啶基-1-丙酮2-Methyl-1,2-di-3-pyridyl-1-propanoneMetyrapone
Properties
Physical Property
Flash Point
>110 °C
>230 °F
Solubility
H2O: <2 mg/mL
DMSO: >20 mg/mL
Apperance
solid
Melting Point
52-55 °C(lit.)
Safety Information
European Hazard Symbols
Harmful (Xn)GHS Precautionary statements
P261-P305+P351+P338
MSDS Link
RTECS
UC3050000
Storage Temperature
room temp
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
GHS Hazard statements
H302-H315-H319-H335
German water hazard class
3
GHS Signal Word
Warning
Safety Statements
26
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
Risk Statements
22-36/37/38
Product Information
Empirical Formula (Hill Notation)
C14H14N2O
Purity
≥98% (HPLC)
Molecule Details
Biochem/physiol Actions
Metyrapone is a glucocorticoid synthesis inhibitor; a standard in assessing adrenal gland function especially in response to stress, as well as pituitary gland function. In addition to acting as a glucocorticoid synthesis inhibitor, Metyrapone also inhibits cytochrome P450-mediated prostaglandin ω/ω-1 hydroxylase activity and impairs learning and memory. Data shows results in activation of the sleep EEG and a robust decrease in quantitative delta sleep.
Metyrapone is a glucocorticoid synthesis inhibitor; a standard in assessing adrenal gland function especially in response to stress, as well as pituitary gland function. In addition to acting as a glucocorticoid synthesis inhibitor, Metyrapone also inhibits cytochrome P450-mediated prostaglandin ω/ω-1 hydroxylase activity and impairs learning and memory. Data shows results in activation of the sleep EEG and a robust decrease in quantitative delta sleep.
Molecular Spectra
No Data Available
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References
No Data Available
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