Substance
ID:348334
Names and Identifiers
IUPAC Traditional name
adefovir dipivoxil
IUPAC name
[({[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}({[(2,2-dimethylpropanoyl)oxy]methoxy})phosphoryl)oxy]methyl 2,2-dimethylpropanoate
Synonyms
9-(2[bis(Pivaloyloxymethoxy)phosphorylmethoxy]ethyl)adenineAdefovir dipivoxil
Properties
Safety Information
Safety Statements
36/37
GHS Hazard statements
H302-H312-H332
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Storage Temperature
-20°C
MSDS Link
GHS Signal Word
Warning
GHS Precautionary statements
P280
Risk Statements
20/21/22
German water hazard class
3
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
European Hazard Symbols
Harmful (Xn)Product Information
Empirical Formula (Hill Notation)
C20H32N5O8P
Molecule Details
Biochem/physiol Actions
Antiviral acyclic nucleoside phosphonate (ANP) analog.
Adefovir is an antiviral acyclic nucleoside phosphonate (ANP) analog.that works by blocking reverse transcriptase 3. It is an inhibitor of duck hepatitis B virus (DHBV) replication that inhibits covalently closed circular DNA (CCC DNA) amplification 4. Cytotxicity is induced by Human Renal Organic Anion Transporter 1 (hOAT1) 5. Adefovir is an Inhibitor of edema factor (EF)-induced cAMP accumulation and changes in cytokine production in mouse primary macrophages 2.
Application
Adefovir is used to treat hepatitis B infections. It is used to study organ-specific toxicity and immune mechanisms of Adefovir treatment 1,2.
Antiviral acyclic nucleoside phosphonate (ANP) analog.
Adefovir is an antiviral acyclic nucleoside phosphonate (ANP) analog.that works by blocking reverse transcriptase 3. It is an inhibitor of duck hepatitis B virus (DHBV) replication that inhibits covalently closed circular DNA (CCC DNA) amplification 4. Cytotxicity is induced by Human Renal Organic Anion Transporter 1 (hOAT1) 5. Adefovir is an Inhibitor of edema factor (EF)-induced cAMP accumulation and changes in cytokine production in mouse primary macrophages 2.
Application
Adefovir is used to treat hepatitis B infections. It is used to study organ-specific toxicity and immune mechanisms of Adefovir treatment 1,2.
Molecular Spectra
No Data Available
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References
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