Substance
ID:348315
Names and Identifiers
IUPAC Traditional name
brefeldin A
IUPAC name
(1R,6S,11aS,13S,14aR)-1,13-dihydroxy-6-methyl-1H,4H,6H,7H,8H,9H,11aH,12H,13H,14H,14aH-cyclopenta[f]oxacyclotridecan-4-one
Synonyms
γ,4-Dihydroxy-2-(6-hydroxy-1-heptenyl)-4-cyclopentanecrotonic acid λ-lactoneCyaneinBrefeldin ADecumbinBFAAscotoxin
Properties
Product Information
Biological Source
from Penicillium brefeldianum
Concentration
10 mg/mL in DMSO
Empirical Formula (Hill Notation)
C16H24O4
Sterility
0.2 μm filtered
Shipped in
wet ice
Safety Information
Storage Temperature
2-8°C
MSDS Link
German water hazard class
2
Personal Protective Equipment
Eyeshields, Faceshields, Gloves, half-mask respirator (US), multi-purpose combination respirator cartridge (US)
Physical Property
Flash Point
87 °C
188.6 °F
Molecule Details
Application
Brefeldin A is produced from Penicillium brefeldianum and is used to study protein transport.
Biochem/physiol Actions
Brefeldin A (BFA) is a fungal metabolite which disrupts the structure and function of the Golgi apparatus by inhibiting transport of proteins from ER to Golgi and inducing retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum. 1 BFA is an activator of the sphingomyelin cycle. Brefeldin A-mediated apoptosis has been observed in human tumor cells.
Brefeldin A (BFA) is a fungal metabolite which disrupts the structure and function of the Golgi apparatus. BFA is an activator of the sphingomyelin cycle. Brefeldin A-mediated apoptosis has been observed in human tumor cells.
Brefeldin A is produced from Penicillium brefeldianum and is used to study protein transport.
Biochem/physiol Actions
Brefeldin A (BFA) is a fungal metabolite which disrupts the structure and function of the Golgi apparatus by inhibiting transport of proteins from ER to Golgi and inducing retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum. 1 BFA is an activator of the sphingomyelin cycle. Brefeldin A-mediated apoptosis has been observed in human tumor cells.
Brefeldin A (BFA) is a fungal metabolite which disrupts the structure and function of the Golgi apparatus. BFA is an activator of the sphingomyelin cycle. Brefeldin A-mediated apoptosis has been observed in human tumor cells.
Molecular Spectra
No Data Available
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References
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