Substance
ID:348310
Names and Identifiers
IUPAC name
2-(2,4-difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)propan-2-ol
IUPAC Traditional name
fluconazole
Synonyms
Fluconazole2-(2,4-Difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)propan-2-ol
Properties
Product Information
Empirical Formula (Hill Notation)
C13H12F2N6O
Purity
≥98% (HPLC)
Safety Information
GHS Hazard statements
H302-H315-H319-H335
European Hazard Symbols
Harmful (Xn)RTECS
XZ4810000
German water hazard class
3
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Risk Statements
22-36/37/38
GHS Signal Word
Warning
MSDS Link
GHS Precautionary statements
P261-P305+P351+P338
Safety Statements
26-36
Storage Temperature
room temp
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
Pharmacology Properties
Gene Information
human ... CYP1A2(1544)
Physical Property
Solubility
DMSO: soluble5 mg/mL
Apperance
powder
Molecule Details
Biochem/physiol Actions
Fluconazole is an antifungal agent. It is highly selective inhibitor of fungal cytochrome P-450 sterol C-14 α-demethyllation. Fluconazole is a potent inhibitor of CYP2C9. Fluconazole interferes with fungal ergosterol synthesis and downregulates the metallothionein gene.
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. F8929.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
Fluconazole is an antifungal agent. It is highly selective inhibitor of fungal cytochrome P-450 sterol C-14 α-demethyllation. Fluconazole is a potent inhibitor of CYP2C9. Fluconazole interferes with fungal ergosterol synthesis and downregulates the metallothionein gene.
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. F8929.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
Molecular Spectra
No Data Available
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References
No Data Available
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