Substance
ID:348310
Names and Identifiers
IUPAC name
2-(2,4-difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)propan-2-ol
IUPAC Traditional name
fluconazole
Synonyms
Fluconazole2-(2,4-Difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)propan-2-ol
Properties
Safety Information
RTECS
XZ4810000
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Safety Statements
26-36
GHS Signal Word
Warning
GHS Precautionary statements
P261-P305+P351+P338
Risk Statements
22-36/37/38
European Hazard Symbols
Harmful (Xn)Storage Temperature
room temp
German water hazard class
3
MSDS Link
GHS Hazard statements
H302-H315-H319-H335
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
Product Information
Empirical Formula (Hill Notation)
C13H12F2N6O
Purity
≥98% (HPLC)
Physical Property
Apperance
powder
Solubility
DMSO: soluble5 mg/mL
Pharmacology Properties
Gene Information
human ... CYP1A2(1544)
Molecule Details
Biochem/physiol Actions
Fluconazole is an antifungal agent. It is highly selective inhibitor of fungal cytochrome P-450 sterol C-14 α-demethyllation. Fluconazole is a potent inhibitor of CYP2C9. Fluconazole interferes with fungal ergosterol synthesis and downregulates the metallothionein gene.
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. F8929.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
Fluconazole is an antifungal agent. It is highly selective inhibitor of fungal cytochrome P-450 sterol C-14 α-demethyllation. Fluconazole is a potent inhibitor of CYP2C9. Fluconazole interferes with fungal ergosterol synthesis and downregulates the metallothionein gene.
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. F8929.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
Molecular Spectra
No Data Available
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References
No Data Available
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