Substance
ID:348190
Names and Identifiers
Synonyms
CFTR(inh)-1725-[(4-Carboxyphenyl)methylene]-2-thioxo-3-[(3-trifluoromethyl)phenyl-4-thiazolidinone
IUPAC name
4-({4-oxo-2-sulfanylidene-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene}methyl)benzoic acid
IUPAC Traditional name
4-({4-oxo-2-sulfanylidene-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene}methyl)benzoic acid
Properties
Product Information
Purity
≥98% (HPLC)
Empirical Formula (Hill Notation)
C18H10F3NO3S2
Physical Property
Solubility
H2O: insoluble
DMSO: ≥10 mg/mL
Apperance
yellow powder
Safety Information
European Hazard Symbols
Nature polluting (N)
Irritant (Xi)MSDS Link
GHS Precautionary statements
P261-P273-P280-P305+P351+P338-P501
Packing Group
3
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
Hazardous to the aquatic environment
Acute hazard, category1
Chronic hazard, categories 1,2
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
GHS Signal Word
Warning
Safety Statements
26-36/37-60-61
Hazard Class
9
German water hazard class
3
GHS Hazard statements
H315-H317-H319-H335-H410
Storage Temperature
2-8°C
UN Number
3077
RID/ADR
UN 3077 9/PG 3
Risk Statements
36/37/38-43-50/53
Molecule Details
Biochem/physiol Actions
CFTR(inh)-172 is an inhibitor of the cystic fibrosis transmembrane conductance regulator (CFTR). With a Ki = 300 nM,. CFTR(inh)-172 leads to rapid, reversible and voltage-independent inhibition; it is an antidiarrheal agent in animals. CTFR(inh)-172 may be a useful tool to study animal models of cystic fibrosis and intestinal fluid loss in cholera and other secretory diarrheas. CTFR(inh)-172 is structurally-unrelated to known, but non-specific CFTR inhibitors DPC, NPPB (Cat. No. N4779) and Glibenclamide.
CFTR(inh)-172 is an inhibitor of the cystic fibrosis transmembrane conductance regulator (CFTR). With a Ki = 300 nM,. CFTR(inh)-172 leads to rapid, reversible and voltage-independent inhibition; it is an antidiarrheal agent in animals. CTFR(inh)-172 may be a useful tool to study animal models of cystic fibrosis and intestinal fluid loss in cholera and other secretory diarrheas. CTFR(inh)-172 is structurally-unrelated to known, but non-specific CFTR inhibitors DPC, NPPB (Cat. No. N4779) and Glibenclamide.
Molecular Spectra
No Data Available
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References
No Data Available
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