Substance
ID:348134
Names and Identifiers
IUPAC name
1-(3-chlorophenyl)-3-(1-methyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl)urea
IUPAC Traditional name
fenobam
Synonyms
FenobamN-(3-Chlorophenyl)-N′-(4,5-dihydro-1-methyl-4-oxo-1H-imidazole-2-yl)urea
Properties
Safety Information
European Hazard Symbols
Toxic (T)GHS Hazard statements
H300
Risk Statements
25
Packing Group
3
German water hazard class
3
MSDS Link
Personal Protective Equipment
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
GHS Precautionary statements
P264-P301+P310
Hazard Class
6.1
UN Number
2811
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), categories 1,2,3
Storage Temperature
2-8°C
GHS Signal Word
Danger
RID/ADR
UN 2811 6.1/PG 3
Safety Statements
45
Product Information
Purity
≥98% (HPLC)
Empirical Formula (Hill Notation)
C11H11ClN4O2
Physical Property
Solubility
DMSO: >20 mg/mL
Apperance
white solid
Molecule Details
Biochem/physiol Actions
Fenobam is a potent, selective, noncompetitive glutamate mGluR5 receptor antagonist. Fenobam displays inverse agonist properties; blocks mGluR5 constitutive activity in vitro (IC50 = 87 nM, slightly weaker than MPEP). Fenobam acts at an allosteric modulatory site shared with MPEP and binds the mGlu5 receptor with Kd values of 54 and 31 nM for rat and human receptors, respectively. Fenobam belongs to a structurally different class than MPEP; devoid of GABAergic activity and thus typical benzodiazepine-like side effects; displays anxiolytic activity.
Fenobam is a potent, selective, noncompetitive glutamate mGluR5 receptor antagonist. Fenobam displays inverse agonist properties; blocks mGluR5 constitutive activity in vitro (IC50 = 87 nM, slightly weaker than MPEP). Fenobam acts at an allosteric modulatory site shared with MPEP and binds the mGlu5 receptor with Kd values of 54 and 31 nM for rat and human receptors, respectively. Fenobam belongs to a structurally different class than MPEP; devoid of GABAergic activity and thus typical benzodiazepine-like side effects; displays anxiolytic activity.
Molecular Spectra
No Data Available
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References
No Data Available
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