Substance
ID:348091
Names and Identifiers
IUPAC name
phenylethynesulfonamide
IUPAC Traditional name
phenylethynesulfonamide
Synonyms
2-PhenylethynesulfonamidePFTμPifithrin-μPFT-μ2-Phenyl-ethynesulfoanide
Properties
Product Information
Empirical Formula (Hill Notation)
C8H7NO2S
Purity
≥97% (HPLC)
Safety Information
MSDS Link
GHS Signal Word
Warning
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
GHS Hazard statements
H302-H315-H319-H335
European Hazard Symbols
Harmful (Xn)Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Safety Statements
26
Storage Temperature
2-8°C
Risk Statements
22-36/37/38
Storage Condition
desiccated
GHS Precautionary statements
P261-P305+P351+P338
German water hazard class
3
Physical Property
Apperance
solid
Solubility
DMSO: >10 mg/mL
H2O: <2 mg/mL
Molecule Details
Biochem/physiol Actions
Pifithrin-μ is an inhibitor of p53 binding and anti-apoptotic, which directly inhibits p53 binding to mitochondria as well as to Bcl-xL and Bcl-2 proteins. PFTμ rescues cells from lethal γ-irradiation-induced cell death. Because pifithrin-μ shuts down only the p53-mitochondrial pathway without affecting the transcriptional functions of p53, it is superior to pifithrin-α.
Pifithrin-μ is an inhibitor of p53 binding and anti-apoptotic, which directly inhibits p53 binding to mitochondria as well as to Bcl-xL and Bcl-2 proteins. PFTμ rescues cells from lethal γ-irradiation-induced cell death. Because pifithrin-μ shuts down only the p53-mitochondrial pathway without affecting the transcriptional functions of p53, it is superior to pifithrin-α.
Molecular Spectra
No Data Available
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References
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